Original contributionHuman and mouse plasmacytoid dendritic cells
Section snippets
Abbreviations
- DC
dendritic cell(s)
- PDC
plasmacytoid DC
- IFN-I
type one interferon
- NIPC
natural interferon producing cell
- BM
bone marrow cells
- FL
Flt3-ligand
- FL-BM
culture of BM in FL supplemented medium
- PAMPS
pathogen associated molecular patterns
- PRR
pattern-recognition receptors
- TLR
toll-like receptor
- LPS
lipopolysaccharide
Identification of plasmacytoid dendritic cells
A cell type with plasmacytoid appearance but displaying a unique set of surface antigens had puzzled pathologists for decades. Based on the expression of lymphoid or myeloid related antigens these obscure cells were named plasmacytoid T cells or plasmacytoid monocytes. [1]. In 1997, Grouard et al. [2] and Olweus et al. [3] reported that plasmacytoid T cells/monocytes had characteristics of precursor dendritic cells (DC) and they were therefore renamed plasmacytoid DC (PDC). On the other hand
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