Elsevier

Human Immunology

Volume 63, Issue 12, December 2002, Pages 1103-1110
Human Immunology

Original contribution
Human and mouse plasmacytoid dendritic cells

https://doi.org/10.1016/S0198-8859(02)00748-6Get rights and content

Abstract

By virtue of their enormous potential to produce type I interferons it is clear that plasmacytoid dendritic cells are major players in the host defense against viruses and various pathogens. Plasmacytoid dendritic cells were first identified in humans and very recently the mouse equivalents have been isolated. This review focuses, where possible, on a comparison between the cells in these two species. The mouse and human plasmacytoid DC are remarkably similar in surface phenotype and they display similar responses to pathogenic stimuli. The discovery of the mouse plasmacytoid dendritic cells has allowed for further biological properties of these cells to be investigated and it is now clear that they represent a long-lived family of cells that differentiate into novel dendritic cells upon microbiologic stimulation.

Section snippets

Abbreviations

    DC

    dendritic cell(s)

    PDC

    plasmacytoid DC

    IFN-I

    type one interferon

    NIPC

    natural interferon producing cell

    BM

    bone marrow cells

    FL

    Flt3-ligand

    FL-BM

    culture of BM in FL supplemented medium

    PAMPS

    pathogen associated molecular patterns

    PRR

    pattern-recognition receptors

    TLR

    toll-like receptor

    LPS

    lipopolysaccharide

Identification of plasmacytoid dendritic cells

A cell type with plasmacytoid appearance but displaying a unique set of surface antigens had puzzled pathologists for decades. Based on the expression of lymphoid or myeloid related antigens these obscure cells were named plasmacytoid T cells or plasmacytoid monocytes. [1]. In 1997, Grouard et al. [2] and Olweus et al. [3] reported that plasmacytoid T cells/monocytes had characteristics of precursor dendritic cells (DC) and they were therefore renamed plasmacytoid DC (PDC). On the other hand

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