Ibuprofen overdose: 126 cases

doi:10.1016/S0196-0644(86)80617-5

Annals of Emergency Medicine

Volume 15, Issue 11, November 1986, Pages 1308-1313

https://doi.org/10.1016/S0196-0644(86)80617-5 Get rights and content

In this study of ibuprofen overdose, symptoms developed in 19% of patients (24 of 126) — in 7% of children (6 of 88) and in 47% of adlts (18 of 38). Central nervous system depression, seizures, gastrointestinal disturbances, bradycardia, hypotension, apnea, abnormal renal functions, hematuria, nystagmus, and blurred vision were observed. No patients became symptomatic more than four hours after ingestion. There was no significant difference (P > .05) between symptomatic and asymptomatic adult groups in either total milligrams or milligram-per-kilogram amounts ingested by history. Pediatric patients who became symptomatic had a mean ingestion by history of 440 mg/kg; those who remained asymptomatic had a mean ingestion by history of 114 mg/kg (P < .001). No patients ingesting less than 99 mg/kg by history developed any symptoms. Two children had seizures or apnea and one died. Ibuprofen occasionally may cause serious toxicity in overdose.

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: Presented in part at the AACT/AAPCC/ABMT/CAPCC Annual Scientific Meeting in Kansas City, Missouri, August 1985.

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Original contributionIbuprofen overdose: 126 cases

Am J Med

Am J Med

J Pharm Sci

Clin Rheumatic Dis

Toxicol Appl Pharmacol

Overdose with ibuprofen causing unconsciousness and hypotension

Br Med J

Poisoning after overdose with non-steroidal anti-inflammatory drugs

Adv Drug React Ac Pois Rev

Acute oliguric renal failure due to ibuprofen overdose

South Med J

Original contribution
Ibuprofen overdose: 126 cases