Review
The host—tumor immune conflict: from immunosuppression to resistance and destruction

https://doi.org/10.1016/S0167-5699(97)01115-8Get rights and content

Abstract

A successful immune response against a tumor is dependent on the cytokine repertoire present at the tumor site. Salem Chouaib and colleagues discuss evidence that, to escope the immune system, tumor cells not only produce immunosuppressive cytokines but also employ strategies involving altered susceptibility to tumor necrosis factor and Fas cytotoxic pathways and, in some circumstances, use of the Fas ligand to neutralize effector cells.

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