Diagnostic use of microsatellite instability in hereditary non-polyposis colorectal cancer
References (12)
- et al.
The international collaborative group on hereditary non-polyposis colorectal cancer (ICG-HNPCC)
Dis Colon Rectum
(1991) - et al.
Replication errors in benign and malignant tumours from hereditary nonpolyposis colorectal cancer patients
Cancer Res
(1994) - et al.
A second-generation linkage map of the human genome
Nature
(1992) - et al.
An Alu variable polyA repeat polymorphism upstream of Lymc at 1p32
Hum Mol Genet
(1992) - et al.
Isolation and characterisation of 19 dinucleotide repeat polymorphisms on chromosome 3p
Hum Mol Genet
(1992)
Cited by (89)
Clustering of Lynch syndrome malignancies with no evidence for a role of DNA mismatch repair
2008, Gynecologic OncologyCitation Excerpt :Little is known about the genetic alterations responsible for cancer in these families. Clinical heterogeneity in familial CRC and HNPCC was recognized early and a subgroup of patients were identified with an older age of cancer onset, MSS tumors located primarily in the left colon and lack of other cancer sites [21]. Families such as these have been characterized more recently by Lindor et al. who have defined these families that meet criteria for HNPCC via Amsterdam I with no mismatch repair deficiency as “familial colorectal cancer type X” [22].
Differences between familial and sporadic forms of colorectal cancer with DNA microsatellite instability
2007, Surgical OncologyCitation Excerpt :However, when cancers were tested for MSI, only those families associated with MSI-H cancers showed the features described by Lynch [33]. Families fulfilling the Amsterdam criteria, but lacking MSI-H cancers the onset of colorectal cancer is at an older age, and there is less cancer multiplicity, no predilection for the proximal colon, more numerous adenomas and a lack of histological features of MSI-H cancers (poor or mucinous differentiation and lymphocytic infiltration) [34,35]. Germline mutations in DNA mismatch repair genes can only be detected in families with MSI-H cancers [36].
Familial Colorectal Cancer Syndrome X
2007, Seminars in OncologyDo hereditary syndrome-related gynecologic cancers have any specific features?
2015, Insights into Imaging