Elsevier

The Lancet

Volume 328, Issue 8499, 19 July 1986, Pages 127-129
The Lancet

CHLOROQUINE-RESISTANT PLASMODIUM FALCIPARUM MALARIA IN ETHIOPIA

https://doi.org/10.1016/S0140-6736(86)91945-8Get rights and content

Abstract

Standard triple-dose therapy with chloroquine (25 mg base/kg) failed to clear asexual Plasmodium falciparum parasites from the blood of 22 of 98 patients infected in various parts of Ethiopia and evaluated in Addis Ababa, a malaria-free city. RI to RIII levels of resistance were demonstrated in those patients. The resistant isolates were confined to areas bordering Somalia, Kenya, and Sudan. In in-vitro tests 7 of 10 (70%) isolates were chloroquine-resistant.

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    2003, Acta Tropica
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    Drug or insecticide resistance usually cause gradual increases in incidence over several years. The levels of drug resistance by P. falciparum and DDT resistance by the major vector Anopheles arabiensis were low in the 1980s in Ethiopia (Teklehaimanot, 1986; Abose et al., 1998), although in the 1990s resistance to chloroquine increased, probably contributing to later epidemics. It has been also reported that high population migration towards the end of the civil war in relation to spreading chloroquine-resistant falciparum malaria might have played a role in the localised epidemics of 1991 (Mengesha et al., 1998).

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