Sphingosine kinases: A novel family of lipid kinases
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2018, Biochimica et Biophysica Acta - Molecular and Cell Biology of LipidsMiR-363-3p suppresses tumor growth and metastasis of colorectal cancer via targeting SphK2
2018, Biomedicine and PharmacotherapyCitation Excerpt :To further explore the mechanism of the anti-tumor effect of miR-363-3p in CRC, we focused on SphK2, one of the key regulators of sphingolipid signaling, although its role in regulating sphingolipid metabolism is not well understood [16]. SphK2 can function both as an oncogene and a tumor suppressor [16]. Early studies have shown that SphK2 could induce cell cycle arrest and apoptosis by accumulating in the nucleus and inhibiting DNA synthesis [30,31].
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2018, Progress in Molecular Biology and Translational ScienceSphingosine metabolism as a therapeutic target in cutaneous melanoma
2017, Translational ResearchCitation Excerpt :In addition, SK1 and SK2 expressions are tissue specific whereby SK1 is more abundant in lung and spleen tissues, while SK2 is more expressed in liver and heart tissues. Intracellularly, SK1 and SK2 seem to localize to different organelles, whereby SK1 is found mainly in the cytosol whereas SK2 can be detected in both cytoplasm and nucleus.59,60 The importance of SK enzymes to human diseases is revealed in the knockout phenotypes; although SphK1 and SphK2 null mice survive, SphK double knockout is embryonically lethal.61