Proteins of the Myc Network: Essential Regulators of Cell Growth and Differentiation
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2022, European Journal of Medicinal ChemistryCitation Excerpt :Further, we concentrated on Bim which similarly to Noxa contains a BH3 domain and induces apoptosis by binding to and antagonizing anti-apoptotic members of the Bcl-2 family, namely Bcl-2, Bcl-xL, Mcl-1, Bcl-w, Bfl-1, and BHRF-1 [40]. Finally, c-Myc, a marker of increased cellular proliferation which is frequently induced in many cancer types was immunodetected [41]. Its expression was markedly decreased as a response to treatments with triterpene derivatives: 1 × IC50 and 5 × IC50 8, 1 × IC50 and 5 × IC50 21, 5 × IC50 22, 5 × IC50 23.
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