Structures of harringtonine, isoharringtonine, and homoharringtonine
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2021, PhytochemistryCitation Excerpt :IR absorptions of 5 showed the characteristic peaks of phenyl (between 3000 and 3300 cm–1) and ester carbonyl (1744 cm−1) groups. 1H and 13C NMR data (Table 1) of 5 corresponded well to those of harringtonine (8) (Powell et al., 1970), except for the aliphatic ester moiety. HMBC correlations of H2-3′ (δH 2.20, d; 1.89, d) with C-1′ (δC 174.6), C-2′ (δC 75.9), and C-1′′ (δC 34.4); H3-5′(δH 3.55, s) with C-4′ (δC 171.8); H2-4′′ (δH 3.31, m) with C-2′′ (δC 32.8), C-3′′ (δC 73.0), and C-5′′ (δC 23.9); H3-5′′ (δH 1.07, s) with C-2′′ (δC 32.8), in combination with 1H–1H COSY cross peak of H2-1′′/H2-2″, revealed the existence of the methyl ester of 2-(3,4-dihydroxy-3-methyl-butyl)-2-hydroxy-succinic acid (Fig. S5).
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