Elsevier

Tetrahedron Letters

Volume 42, Issue 27, 2 July 2001, Pages 4495-4497
Tetrahedron Letters

Towards the synthesis of C-glycosylated dihydropyrimidine libraries via the three-component Biginelli reaction. A novel approach to artificial nucleosides

https://doi.org/10.1016/S0040-4039(01)00769-9Get rights and content

Abstract

The Lewis acid catalyzed (BF3·Et2O, CuCl, AcOH) one-pot three-component cyclocondensation of urea with C-glycosylated aldehydes and β-keto esters (Biginelli reaction) in a combinatorial manner afforded three different series of 3,4-dihydropyrimidin-2(1H)-ones bearing C-glycosyl moieties at C4, C6, and at both C4 and C6.

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Acknowledgments

We gratefully thank the University of Ferrara for financial support.

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