Elsevier

Metabolism

Volume 46, Issue 2, February 1997, Pages 217-223
Metabolism

Effect of prolonged exercise training without weight loss on high-density lipoprotein metabolism in overweight men

https://doi.org/10.1016/S0026-0495(97)90305-XGet rights and content

Abstract

This study examined the effect of exercise training without weight loss on high-density lipoprotein (HDL) metabolism in overweight men. We evaluated HDL metabolism using 125I-radiolabeled autologous HDL in 17 overweight men aged 40 ± 7 years (mean ± SD) before and after 1 year of exercise training. Subjects consumed defined diets in a metabolic kitchen during the metabolic studies. They performed endurance exercise under supervision for 1 hour four times weekly and maintained their pretraining body weight. Maximal oxygen uptake (Vo2max) increased 27% (P < .001) with exercise training. HDL-cholesterol (HDL-C) and apolipoprotein (apo) A-I increased 10% and 9%, respectively (P < .001 for both), whereas triglycerides and apo B decreased 7% and 10%, respectively (P < .05). Postheparin lipoprotein lipase increased 11% (P = NS). Hepatic triglyceride lipase activity (HTGLA) decreased 12% (P < .05). The fractional catabolic rate (FCR) of HDL protein and of apo A-I decreased 5% and 7%, respectively (P < .05 for both). The synthetic rate of apo A-I increased 13% (P < .01). Increased HDL after exercise training is associated with both decreased HDL protein catabolism and increased HDL apo A-I synthesis. Weight loss is not required to increase HDL-C with exercise training in overweight men, but without weight loss, even prolonged exercise training produces only modest changes in HDL-C concentrations.

References (28)

  • PD Wood et al.

    Plasma lipoprotein distributions in male and female runners

    Ann NY Acad Sci

    (1977)
  • PD Wood et al.

    Changes in plasma lipids and lipoproteins in overweight men during weight loss through dieting as compared with exercise

    N Engl J Med

    (1988)
  • PD Thompson et al.

    Modest changes in high-density lipoprotein concentrations and metabolism with prolonged exercise training

    Circulation

    (1988)
  • MF Najjar et al.

    Anthropometric Reference Data and Prevalence of Overweight, United States, 1976-80

  • Cited by (113)

    • The metabolic and pharmacologic bases for treating atherogenic dyslipidaemia

      2014, Best Practice and Research: Clinical Endocrinology and Metabolism
    • Impact of diet and exercise on lipid management in the modern era

      2014, Best Practice and Research: Clinical Endocrinology and Metabolism
      Citation Excerpt :

      The impact of exercise training on apolipoproteins has been previously described [8,9]. Generally, apo A-I levels are increased [13] or unchanged [14]. Apo B alterations following exercise training usually parallel LDL-C changes [15].

    • Aerobic training and lipid profile of hypothyroid rats

      2013, Revista Andaluza de Medicina del Deporte
    • Effects of physical activity on cardiovascular disease

      2012, American Journal of Cardiology
      Citation Excerpt :

      To date, most studies noting reduction in total cholesterol or LDL were in the setting of significant exercise-induced weight loss. In fact, most data regarding exercise training and serum lipids seem to indicate that regular exercise training does not significantly reduce total cholesterol or LDL independent of weight loss (Table 1).3–7 Randomized trials studying the effect of aerobic exercise and comprehensive rehabilitation in patients with CAD noted no change in LDL or total cholesterol after ≥6 months of intervention.5–7

    View all citing articles on Scopus

    Supported by National Institutes of Health Grant No. HL-28467 and by the Miriam Foundation, the Haire Family, William Jakober, and the McNulty Family.

    View full text