Amelioration of insulin resistance and hypertension in a fructose-fed rat model with fish oil supplementation☆
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Replacement of soybean oil by fish oil increases cytosolic lipases activities in liver and adipose tissue from rats fed a high-carbohydrate diets
2018, Journal of Nutritional BiochemistryCitation Excerpt :Our present results (Fig. 2A) corroborate previous studies [39,40] showing that a FRUC-SO does not induce glucose intolerance when compared with AIN-SO. Dietary lard replacement by FO in a high-fat diet improves glucose tolerance in rodents [4,41,42], but the FO supplementation of a high-fructose diet does not change the glucose tolerance in Sprague-Dawley rats and rhesus monkeys [43,44]. In Wistar rats, the replacement of (n-6) PUFA in a high-fructose diet by (n-3) PUFA as a mix of α-linolenic acid (ALA), EPA and DHA induces an increase in the area under the curve during the glucose tolerance test after 8 weeks but not after 4 weeks [39].
Fish Oil Fatty Acids and Vascular Reactivity
2013, Bioactive Food as Dietary Interventions for Cardiovascular DiseaseFish Oil Fatty Acids and Vascular Reactivity
2012, Bioactive Food as Dietary Interventions for Cardiovascular Disease: Bioactive Foods in Chronic Disease StatesN-3 polyunsaturated fatty acids regulate lipid metabolism through several inflammation mediators: mechanisms and implications for obesity prevention
2010, Journal of Nutritional BiochemistryObesity: Genes, brain, gut, and environment
2010, NutritionCitation Excerpt :Afferent vagus nerves from the liver and efferent sympathetic nerves to adipose tissues regulate energy expenditure, systemic insulin sensitivity, glucose metabolism, and fat distribution between the liver and the periphery [24]. Proinflammatory cytokine production is regulated by the efferent vagal “cholinergic anti-inflammatory pathway” mediated by acetylcholine [132–134], which is a neurotransmitter and regulator of release and actions of serotonin, dopamine, and other neuropeptides [135]; whereas PUFAs (LCFAs) influence acetylcholine release [136,137] and insulin sensitivity [138–143], suggesting that an interaction(s) exists among these molecules in the regulation of energy homeostasis. Brain insulin resistance exists in peripheral insulin resistance, especially in regions subserving appetite and reward [144]; and exercise enhances the sensitivity of hypothalamus to the actions of leptin and insulin and the appetite-suppressive actions of exercise are mediated by the hypothalamus [145].
Is metabolic syndrome X a disorder of the brain with the initiation of low-grade systemic inflammatory events during the perinatal period?
2007, Journal of Nutritional Biochemistry
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Supported by grants from the Department of Health (DOH 85-HR-312), the National Science Council (NSC 85-2331-B-075-081), and the Veterans General Hospital research fund (VGH 86-291).