Alendronate induces gastric injury and delays ulcer healing in rodents
References (28)
Gastroenterology
(1989)- et al.
Gastroenterology
(1995) - et al.
Gastroenterology
(1989) - et al.
Gastroenterology
(1995) - et al.
Gastroenterology
(1995) - et al.
Gastroenterology
(1994) - et al.
J. Chromatogr.
(1979) - et al.
The Lancet
(1996) - et al.
Bone
(1994) Gastroenterology
(1997)
J. Pharmaceut. Sci.
Gastroenterology
Am. J. Med.
Arthritis Rheum.
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Reduced food interaction and enhanced gastrointestinal tolerability of a new system based on risedronate complexed with Eudragit E100: Mechanistic approaches from in vitro and in vivo studies
2016, European Journal of Pharmaceutics and BiopharmaceuticsCitation Excerpt :Again, all differences were statistically significant (p < 0.0001). It is known that gastric damage caused by aminobisphosphonates is a result of their topical irritant effects on the mucosa [29,41,42]. Thus, the reduction in the gastric irritation potential observed with the EuE100-Ris50 treatment could have been related to the reduction in the concentration of free Ris observed in this work.
Alendronate-calcium phosphate hybrid films promoted the osteoblast differentiation and inhibited osteoclastogenic activity
2015, Journal of Industrial and Engineering ChemistryCitation Excerpt :OB synthesizes extracellular matrix proteins including collagen and non-collagenous proteins and regulates matrix mineralization [15]. OC is a highly specialized multinucleate giant cell differentiated from monocyte/macrophage lineage of bone marrow hematopoietic cells and responsible for bone resorption [16,17]. Interestingly, two factors including macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-κB ligand (RANKL) required for OC formation, survival and function, are provided by bone marrow OBs [18].
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2013, Progress in Crystal Growth and Characterization of MaterialsCitation Excerpt :The classic BPs treatment is the systemic way by oral administration or intravenous injection. However, undesirable side-effects like fever [265], ulcers [266,267] or osteonecrosis of the jaw [267,268] are commonly observed by systemic use of BPs. Moreover low bioavailability is commonly observed for oral administration [269].
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2013, Acta MaterialiaRole of soluble guanylate cyclase activation in the gastroprotective effect of the HO-1/CO pathway against alendronate-induced gastric damage in rats
2013, European Journal of PharmacologyCitation Excerpt :Some works have demonstrated that CO activates sGC (Ryter and Otterbein, 2004; Morita et al., 1995) and ODQ treatment completely abolished the protective effect of HO-1 against non-steroidal anti-inflammatory drugs and ethanol-induced gastric damage (Gomes et al., 2010; Freitas et al., 2006). Several studies have suggested that bisphosphonates have a direct irritant effect on the gastric mucosa (Graham and Malaty, 1999; Blank et al., 1997; Elliott et al., 1998), i.e., to decrease the hydrophobic barrier (Lichtenberger et al., 2000). This damaging effect is not due to a decline in the levels of mucosal prostaglandins (Marshall et al., 2000), but through topical irritant action.