Brief clinical and laboratory observation
Plasma creatinine and urea concentration in children: Normal values for age and sex**

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    The Scr level then remains relatively stable for the next 2 years as the infant accrues muscle mass proportionally to the GFR increase. Beyond this, once GFR normalized to body surface area has fully matured, the ongoing accrual of muscle leads to a progressive rise in Scr, especially in boys, until adolescence when adult levels are achieved.20,21 Additionally, although predominantly eliminated by glomerular filtration, a small but variable amount (∼10%) of creatinine is excreted by tubular secretion and gastrointestinal degradation.22-24

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    Monitoring renal function and appropriate medical interventions are important to prevent progressive chronic kidney disease (CKD) and ESRD. In clinical practice, estimated glomerular filtration rate (eGFR), which is calculated from serum creatinine level using estimating equations, is commonly used to define kidney function.29,30 However, creatinine-based estimates of GFR have many limitations that may be relevant for populations with CGCs, particularly spina bifida.31

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Supported in part by National Institutes of Health Grant No. AM14877. Dr. Schwartz is supported by the Research Fellowship Award of the National Institutes of Health No. AM00129.

1

Dr. Haycock is supported in part by the Kidney Foundation of New York and by Kidney Disease Institute Grant No. C 7111.

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