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The PPAR-γ ligand 15-deoxyΔ12,14 prostaglandin J2 reduces the liver injury in endotoxic shock

https://doi.org/10.1016/S0014-2999(03)02179-4Get rights and content

Abstract

We demonstrate here for the first time that the endogenous cyclopentenone prostaglandin 15-deoxy-Δ12,14-prostaglandin J2 (15d-prostaglandin J2) reduces the liver injury (rise in serum transaminases) caused by severe endotoxaemia (6 mg/kg Escherichia coli endotoxin i.v. for 6 h) in the anaesthetised rat. The protection of the liver afforded by this potent agonist of PPAR-γ was not secondary to a haemodynamic effect. Thus, 15d-prostaglandin J2 and other PPAR-γ agonists may be useful in the therapy of septic shock.

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Acknowledgments

M.C. is supported by Academy of Finland, Paavo Nurmi Foundation and Farmos Research Foundation.

References (7)

  • S. Cuzzocrea et al.

    Pyrrolidine dithiocarbamate attenuates the development of acute and chronic inflammation

    Br. J. Pharmacol.

    (2002)
  • K. Guyton et al.

    Peroxisome proliferator-activated receptor-gamma agonists modulate macrophage activation by Gram-negative and Gram-positive bacterial stimuli

    Shock

    (2003)
  • M. Ricote et al.

    The peroxisome proliferator activated receptor-gamma is a negative regulator of macrophage activation

    Nature

    (1998)
There are more references available in the full text version of this article.

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