Ribonuclease activity in human plasma
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Cited by (30)
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2022, Current Research in Pharmacology and Drug DiscoveryCitation Excerpt :These indicators have become increasingly exact and trustworthy throughout time, owing to human technology developments. The assumption that RNA molecules could not be utilized as biomarkers from blood samples due to the elevated amounts of nucleases found in plasma was debated for a while (Kamm and Smith, 1972a,b), but it was eventually abandoned following the revealed as miRNAs remained resilient in samples of fixed tissues (Xi et al., 2007). In 2008, Lawrie et al. (2008) used miRNAs to analyze the serum of patients with diffuse large B-cell lymphoma as biomarkers for cancer; since then, potential major applications of miRNAs as biomarkers for several diseases has been discussed in the scientific literature.
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2018, Trends in MicrobiologyCitation Excerpt :Microbes can release naked RNA into the environment upon cell death [23] or via active secretion systems [24]. However, RNAs in the extracellular environment can be rapidly degraded by abundant ribonucleases (RNases) [25]. Alternatively, engulfed viable and nonviable microbes might release RNA from within the host cell.
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2013, Journal of Lipid ResearchCitation Excerpt :These findings open up a new and exciting frontier in our understanding of how miRNAs and other ncRNAs may be mediating cell-cell and even cross-kingdom communication. When RNA was first detected in the circulation in the early 1970s (40), it was immediately noted that despite the very high levels and activity of RNases present in human plasma, it was surprisingly resistant to nuclease degradation (41). This protection from nuclease degradation was also described for miRNAs in the circulation.
Inducers and induction of interferons
1977, Pharmacology and Therapeutics, Part A: Chemotherapy, Toxicology and