Metal ion induced autoimmunity

doi:10.1016/0952-7915(95)80056-5

Current Opinion in Immunology

Volume 7, Issue 6, December 1995, Pages 831-838

https://doi.org/10.1016/0952-7915(95)80056-5 Get rights and content

Abstract

Metal-induced autoimmunity is a well established but poorly understood phenomenon. Recent work has begun to elucidate the molecular interactions of metal ions with immune cells and self-proteins. Metal-induced presentation of cryptic self-peptides emerges as a possible mechnism for activation of ‘metal-specific’ T cells, challenging the hypothesis of a random polyclonal activation of T and B cells by metals. A preferential T-helper cell type 2 response is involved in metal ion induced systemic autoimmune disease.

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View full text

Metal ion induced autoimmunity

Abstract

Lab Invest

Metal Based Drugs

Annu Rev Immunol

J Exp Med

Scand J Immunol

Scan J Immunol

J Immunol

Tox Appl Pharmacol

Acute mercury intoxication with lichenoid drug eruption followed by mercury contact allergy and development of antinuclear antibodies

Acta Derm Venereol

Systemic autoimmune disease in a patient with long-standing exposure to mercury

Eur J Dermat

Does amalgam affect the immune system? A controversial issue

Int Arch Allergy Immunol

TH2 cells in systemic autoimmunity: insights from allogeneic diseases and chemically-induced autoimmunity

Immunol Today

Autoantibodies to myeloperoxidase in Brown Norway rats treated with mercuric chloride

Lab Invest

Autoantibodies to the laminin P1 fragment in HgCl2-induced membranous glomerulopathy

Am J Pathol

The fine specificity of disease-associated anti-fibrillarin autoantibodies compared with that of HgCl2-induced autoantibodies

Mol Biol Rep

Analysis of the autoantibody response of fibrillarin in human disease and murine models of autoimmunity

J Immunol

In vitro effects of HgCl2 on murine lymphocytes 1. Preferable activation of CD4(+) T cells in a responder strain

J Immunol

Redox mechanism as alternative to ligand binding for receptor activation delivering disregulated cellular signals

J Immunol

Mercuric chloride, a chemical responsible for Th2-mediated autoimmunity in Brown Norway rats, directly triggers T cells to produce IL-4

J Clin Invest

Mercury-induced autoreactive anti-class II T cell line protects from experimental autoimmune encephalomyelitis by the bias of CD8+ antiergotypic cells in Lewis rats

J Exp Med

Mercuric chloride-induced autoimmunity in mice involves an upregulated presentation of altered and unaltered nucleolar self antigen

Int Arch Allergy Immunol

Murine systemic autoimmune disease induced by mercuric chloride (HgCl2): Hg-specific helper T-cells react to antigen stored in macrophages

Int I Immunophamacol

Murine systemic autoimmune disease induced by mercuric chloride: T helper cells reacting to self proteins

Int Arch Allergy Immunol

Self reactive anti-class II Th2 cell lines derived from gold salt-injected rats trigger B cell polyclonal activation and transfer autoimmunity in CD8-depleted normal syngeneic recipients

Eur J Immunol

Dominance and crypticity of T cell antigenic determinants

Annu Rev Immunol

Redoc chemistry and [Au(CN)2−] in the formation of gold metabolites

Metal Based Drugs

Phagocytes render chemicals immunogenic: oxidation of gold(I) to the T-cell sensitizing gold(III) metabolite generated by mononuclear phagocytes

Arch Toxicol

Autoantibodies to the laminin P1 fragment in HgCl₂-induced membranous glomerulopathy

The fine specificity of disease-associated anti-fibrillarin autoantibodies compared with that of HgCl₂-induced autoantibodies

In vitro effects of HgCl₂ on murine lymphocytes 1. Preferable activation of CD4(+) T cells in a responder strain

Mercury-induced autoreactive anti-class II T cell line protects from experimental autoimmune encephalomyelitis by the bias of CD8⁺ antiergotypic cells in Lewis rats

Murine systemic autoimmune disease induced by mercuric chloride (HgCl₂): Hg-specific helper T-cells react to antigen stored in macrophages

Redoc chemistry and [Au(CN)_2⁻] in the formation of gold metabolites