Research report
Auditory M100 component 1: relationship to Heschl's gyri

https://doi.org/10.1016/0926-6410(94)90016-7Get rights and content

Abstract

This study was designed to localize the neuroanatomic generator of the 100 ms latency magnetic auditory evoked field (EF) component (M100) activated by an unattended tone pip. Magnetic EFs in response to 25 ms duration, 90 dB, 1 kHz tone pips were recorded from both hemispheres of nine normal adults, five males and four females, using a seven-channel second-order gradiometer. The source of the M100 was estimated, with confidence intervals, bu a least squares based inverse solution algorithm. Magnetic resonance (MR) images of the brain were acquired with a 1.5 T system using a standard head coil. The superior temporal gyri (STG) were manually segmented from 1.7 mm thick coronal images, and the superior surfaces were then rendered from the 3-D volume data. Translation and rotation matrices were identified to locate the magnetoencephalography (MEG) determined sources within the reconstructed STGs. This population of 18 STGs in 9 individuals demonstrated two transverse gyri in 4 of 9 left hemispheres, and 5 of 9 right hemispheres. All 9 left hemisphere M100 sources were in or included Heschl's gyrus(i) in the confidence intervals. Seven of the 9 included Heschl's gyrus(i) on the right; the remaining two, both males, had sources slightly anterior to Heschl's gyrus(i). We conclude that all M100 source location estimates were compatible with an auditory koniocortex source in or adjacent to Heschl's gyri.

References (29)

  • F. Aboitiz et al.

    Morphometry of the sylvian fissure and the corpus callosum, with emphasis on sex differences

    Brain

    (1992)
  • M. Annett

    A classification of hand preference by association analysis

    Br. J. Psychol.

    (1970)
  • K. Brodmann

    Verglichende Lokalisationslehre der Grosshirnrinde

    Barth

    (1909)
  • J. Edrich et al.

    Doorless and economic shield for clinical magnetoencephalography

    Proceedings of BIOMAG

    (1993)
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