Elsevier

Schizophrenia Research

Volume 14, Issue 1, December 1994, Pages 23-28
Schizophrenia Research

Cerebral ventricular enlargement in schizophreniform disorder does not progress A seven year follow-up study

https://doi.org/10.1016/0920-9964(94)90005-1Get rights and content

Abstract

Ten patients, who underwent computerized tomography (CT) study during evaluation for first episode schizophreniform psychosis were restudied an average of 7 years later. Of the 10 patients, 7 were found to carry a diagnosis of schizophrenia at follow-up. In this subgroup, there was no significant change in the mean ventricular brain ratio measure of cerebral ventricular size between the index and follow-up scans. These findings are consistent with the hypothesis that ventricular enlargement is present at the onset of schizophrenia and does not progress with duration of illness or treatment.

References (25)

  • H.E. Cannon-Spoor et al.

    Measurement of premorbid adjustment in chronic schizophrenia

    Schizophr. Bull.

    (1982)
  • G. Degreef et al.

    Volumes of ventricular system subdivisions measured from magnetic resonance images in first-episode schizophrenic patients

    Arch. Gen. Psychiatry

    (1992)
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    These data were first presented at the American College of Neuropsychopharmacology Annual Meeting in Puerto Rico, 1990.

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