Cerebral ventricular enlargement in schizophreniform disorder does not progress A seven year follow-up study☆
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Workshop on defining the significance of progressive brain change in schizophrenia: December 12, 2008 American College of Neuropsychopharmacology (ACNP) all-day satellite, Scottsdale, Arizona. The rapporteurs' report
2009, Schizophrenia ResearchCitation Excerpt :There were initially some early CT studies as mentioned above that failed to show that ventricular enlargement occurred subsequent to the first episode, but these studies were fraught with methodological problems. While they were used as evidence suggesting a neurodevelopmental basis for ventricular enlargement, when examined closely they actually showed very noisy data from time one to time two, no controls for comparison, variable time points between scans, and measurements of only one slice, thus lacking sensitivity to detect more subtle changes (Jaskiw et al., 1994; Vita et al., 1988, 1994; Sponheim et al., 1991; Kemali et al., 1989). However, even when examining the major new independent first-episode studies to date, the data, while overall suggesting progressive change, are not consistently confirmed when specific anatomical regions are considered.
Schizophrenia as a progressive brain disease
2008, European PsychiatryCitation Excerpt :Moreover, support for a neurodevelopmental model that explains the aetiology of schizophrenia is derived from the notion that much of the abnormalities are present at illness onset and that these structural abnormalities remain stable over time. Indeed, some early longitudinal pneumoencephalography and CT studies reported progressive increase in ventricular size in a cohort over time [60,79,140], but the majority did not [31,65,70,72,98,119,130,131]. Based on these findings we compared patients in a first psychotic episode with healthy age and gender matched individuals.
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These data were first presented at the American College of Neuropsychopharmacology Annual Meeting in Puerto Rico, 1990.