ArticleEffect of motility and chemotaxis on the invasion of Salmonella typhimurium into HeLa cells☆
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Ginsenoside Rg3 reduces the adhesion, invasion, and intracellular survival of Salmonella enterica serovar Typhimurium
2021, Journal of Ginseng ResearchCitation Excerpt :Therefore, the downregulation of hilA gene and other virulence factors that correlate with the activation of hilA by Rg3 could contribute to the reduction in the invasion of S. Typhimurium into host cells. The study confirmed that Rg3 decreased the motility of S. Typhimurium, which is one of the most significant events during cellular invasion [45]. The direction of flagellar rotation is the determining factors for the motility of bacteria [46].
Inhibitory potential of Buffalo (Bubalus bubalis) colostrum immunoglobulin G on Klebsiella pneumoniae
2016, International Journal of Biological MacromoleculesIntestinal invasion of Salmonella enterica serovar Typhimurium in the avian host is dose dependent and does not depend on motility and chemotaxis
2013, Veterinary MicrobiologyCitation Excerpt :A possible simple explanation is that each bacterium that reaches the epithelial cell has an equal chance of invading. Previous studies have concluded that flagella and chemotaxis genes are important for the intestinal phase of S. Typhimurium infection, mostly based on studies of the interaction with cultured epithelial cells and mice (Khoramian-Falsafi et al., 1990; Jones et al., 1992; Schmidt et al., 2001). Similar observations have been made for S. Enteritidis flagella mutants in human and avian cell lines (Van Asten et al., 2000; La Ragione et al., 2003) and in the rat (Robertson et al., 2003).
A flagellated motile Salmonella Gallinarum mutant (SG Fla<sup>+</sup>) elicits a pro-inflammatory response from avian epithelial cells and macrophages and is less virulent to chickens
2013, Veterinary MicrobiologyCitation Excerpt :Although the presence of flagella conferred increased invasiveness to SG Fla+ when compared to SG, the recovery of this mutant from CKC remained lower than that of SE. According to Khoramian-Falsafi et al. (1990), motility, in addition to flagellation, is important for invasion of epithelial cells by Salmonella spp. In this study, we showed that The poorer motility of the SG Fla+ strain in comparison with SE, as illustrated by the reduced movement on semi-solid agar (Fig. S2) could explain, in part, the higher in vitro invasiveness of SE.
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This work was supported by the Fonds National Suisse de la Recherche Scientifique to JCP (Grant 31-28007.89).