ArticleEffect of light intensity on diurnal sleep-wake distribution in young and old rats
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Age-related changes in circadian rhythms and non-visual responses to light during adulthood
2023, Encyclopedia of Sleep and Circadian Rhythms: Volume 1-6, Second EditionSex differences in age-related changes in the sleep-wake cycle
2017, Frontiers in NeuroendocrinologyCitation Excerpt :Aging is fairly consistently associated with sleep fragmentation (shorter sleep bouts) (Mendelson and Bergmann, 1999a; Zepelin et al., 1972; Rosenberg et al., 1979); however, one study reported no change in either the number or the duration of wake, NREM and REM sleep bouts in both Fischer 344 and Sprague-Dawley male rats (Shiromani et al., 2000). Although total sleep time does not appear to change with age, the light/dark ratio of sleep or the amplitude of day/night sleep rhythm decreases with age under light:dark (L:D) 12:12 conditions (Li and Satinoff, 1995; Rosenberg et al., 1979; Van Gool and Mirmiran, 1983; Witting et al., 1993). However, one study using a constant dim light condition immediately following an L:D 12:12 condition, reported no age-related changes in the “light/dark” ratio of total, NREM or REM sleep amounts (Mendelson and Bergmann, 1999a).
Neuronal Firing Rate Homeostasis Is Inhibited by Sleep and Promoted by Wake
2016, CellCitation Excerpt :To differentiate wake and sleep states, we performed polysomnography using local field potentials, electromyogram (EMG), and video recordings to separate activity into epochs of sleep (rapid eye movement, REM; and slow-wave, non-REM; sleep), as well as epochs of quiet and active wake (Figure 2A; Frank et al., 2001). As expected (Witting et al., 1993), animals slept more in the light (∼7/12 hr) than the dark (∼5/12 hr) (Figures S3C–S3F), and in both phases cycled between many brief bouts of sleep and wake, with the average bout length being 17.98 ± 0.55 min and 18.21 ± 0.67 min, respectively. Consistent with a previous report (Hengen et al., 2013), when FRs of individual neurons were normalized and averaged, there was no difference between states, although there was a non-significant trend toward slower rates during NREM (ANOVA = 0.08; Figures 2B and S3A).
Age-Related Changes in Circadian Rhythms During Adulthood
2013, Encyclopedia of SleepAge-Related Changes in Circadian Rhythms During Adulthood
2013, Encyclopedia of Sleep