Biochimica et Biophysica Acta (BBA) - General Subjects
Purification of hepatic microsomal cytochromes P-450 from β-naphthoflavone-treated Atlantic cod (Gadus morhua), a marine teleost fish
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2018, Marine Pollution BulletinCitation Excerpt :The fish liver is a key organ that controls many vital functions and plays a prominent role in fish physiology, both in anabolism and catabolism, as well as in the metabolism of xenobiotics, and it is considered a good indicator of the health status of a fish (Bruslé and Anadon, 1996; Ghosh et al., 2001; Desantis et al., 2005; Cionna et al., 2006; Kirchhoff et al., 2011; Corriero et al., 2013; Passantino et al., 2014). Cytochrome P450 monooxygenase 1A (CYP1A) is a subfamily of the cytochrome P450-dependent monooxygenase enzymes and plays an important role in the biotransformation of many xenobiotics including dioxins, furans, polychlorinated biphenyls, polyaromatic hydrocarbons (PAHs), and dichlorodiphenyltrichloroethane (DDT) (Stegeman, 1978; Goksøyr, 1985; Parkinson, 1995; Husøy et al., 1996; Jeong and Kim, 2002). As a consequence, the expression of CYP1A in the liver may increase following exposure to a variety of organic environmental pollutants (Stegeman, 1978; Goksøyr, 1985; Parkinson, 1995; Husøy et al., 1996; Jeong and Kim, 2002).
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2014, Aquatic ToxicologyCitation Excerpt :The liver is the main site of detoxification in cod, and expresses a wide range of components of the biotransformation system, such as nuclear receptors (xenobiotic sensors) and cytochrome P450 (CYP) enzymes. Knowledge of the biotransformation enzymes and responses in cod is well established (Goksøyr, 1985; Goksøyr et al., 1986, 1987, 1988; Goksøyr and Solberg, 1987; Karlsen et al., 2012). The vertebrate liver is also the site where many environmental compounds tend to accumulate.
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2013, Toxicology and Applied PharmacologyMass spectrometric analyses of microsomal cytochrome P450 isozymes isolated from β-naphthoflavone-treated Atlantic cod (Gadus morhua) liver reveal insights into the cod CYPome
2012, Aquatic ToxicologyCitation Excerpt :β-Naphthoflavone belongs to the class of PAHs and is a potent agonist of the AhR transcription factor, and a standard CYP1A inducer in both mammals and fish (Haasch et al., 1994; Kloepper-Sams and Stegeman, 1989; Lemaire et al., 1996). Four CYP-containing fractions (P-450a–d) have previously been purified (to different degrees of purity) from liver microsomes of β-naphthoflavone-treated Atlantic cod (Goksøyr, 1985). The four putative isozymes were characterized and distinguished with regard to optical properties, enzymatic activity, molecular weight and immunological reactivity (Goksøyr, 1985; Goksøyr et al., 1986).
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