Synthesis and aldose reductase inhibitory activity of acetic acid derivatives of pyrrolo[1,2-c]imidazole
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A route to access imidazol[1,5-: A] indole-1,3-diones and pyrrolo[1,2-c] imidazole-1,3-diones
2019, Organic and Biomolecular ChemistrySynthesis and biological activity of 4-aryl-3-benzoyl-5- phenylspiro[pyrrolidine-2.3′-indolin]-2′-one derivatives as novel potent inhibitors of advanced glycation end product
2014, European Journal of Medicinal ChemistryCitation Excerpt :Substituted piperidinyl glycinyl 2-cyano-4,5-methano pyrrolidines and cyano-pyrrolidine derivatives were evaluated as potent and stable dipeptidyl peptidase IV inhibitors, thus useful for the treatment of diabetes [35,36]. Many pyrrolo[1,2-c]imidazole-1,3-dione moieties and their analogs rosiglitazone and pioglitazone have been developed as potent inhibitors of aldose reductase and were proposed as anti-diabetic agents [37,38]. Polyhydroxylated pyrrolizidine alkaloids, Uniflorine and Alexine, and many dispiropyrrolidine derivatives synthesized through 1,3-dipoar cycloaddition of azomethine ylides have also been found to be anti-diabetic in nature [39–41].
Synthesis and in vitro anticancer activity of 2,4-azolidinedione-acetic acids derivatives
2009, European Journal of Medicinal ChemistryCitation Excerpt :Lately, new biological effects as well as a number of biological targets for these compounds have been discovered, paving the way for drug-like substances design on their basis. For example, Epalrestat (Z,E-[5-(2-methyl-3-phenyl-allylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-acetic acid) and its related analogues are effective aldose reductase inhibitors [7,8]. Amides of 5-arylidene-2-thioxo-4-thiazolidone-3-alkanecarboxylic and 5-(4-fluoro(chloro)phenylmethylidene)-2,4-thiazolidinedione-3-acetic acids possess marked anti-inflammatory activity [9,10].