Original contributionThe role of IgE-mediated hypersensitivity in otitis media with effusion☆
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Cited by (54)
Otitis media with effusion and atopy: Is there a causal relationship?
2017, World Allergy Organization JournalCitation Excerpt :The likelihood of AR and asthma were found higher in patients with serous than with mucous effusion [72]. IgE-mediated allergy has long been considered a causative factor in about one third of recurrent OME patients based on clinical observations and skin testing [73-75]. A meta-analysis of 24 studies revealed that the presence of atopy increased the risk of chronic and recurrent otitis media (OR, 1.36; 95% CI, 1.13–1.64; p = 0.001) [76].
The Role of Allergy in Otitis Media with Effusion
2011, Otolaryngologic Clinics of North AmericaExpression of GATA3, T-bet, IL-4, and IFN-γ mRNA in the effusion of OME patients
2009, International Journal of Pediatric OtorhinolaryngologyCitation Excerpt :For example, the development and pathophysiology of OME may be due to inflammatory responses to bacterial infection in the Eustachian-tubes, resulting in the infiltration of inflammatory cells and various inflammatory mediators [3]. The role of allergy in otitis media, however, is unclear, since 10–80% of these patients have been reported to have allergies [4]. In contrast, the mucosa covering the Eustachian tube rather than the middle ear mucosa has been reported to be a target of allergies [5].
Prevalence of tympanometric alterations in children with chronic sinusitis
2008, International Journal of Pediatric OtorhinolaryngologyCitation Excerpt :The prevalence of OME in children has been estimated in the last three decades in a wide range from 15% to 80% [7–10]. According to a number of studies the presence of sinusitis in children with OME ranges from 48% to 62% [11–13], and concerning the role of allergy some Authors reported that from 23% to 90% of children with OME had hypersensitivity to inhalant allergens [14–17], a range too large to help in clinical practice. We sought to evaluate in children with chronic sinusitis, diagnosed by clinical criteria from a large group of patients with chronic respiratory symptoms, the prevalence of middle ear dysfunction, as assessed by tympanometry, and the prevalence of respiratory allergies.
International consensus statement on allergy and rhinology: Allergic rhinitis – 2023
2023, International Forum of Allergy and RhinologyThe Relation of Allergy to Eustachian Tube Dysfunction and the Subsequent Need for Insertion of Pressure Equalization Tubes
2020, Ear, Nose and Throat Journal
- ☆
This project was funded by Ventrex Laboratories, Inc, Portland, ME, and was performed at the Department of Otolaryngology, West Virginia University School of Medicine, Morgantown, WV; and also presented at the Southern Section Triologic Meeting held in White Sulphur Springs, WV, January 1990.
- 1
Dr. Adham is in private practice in Beaufort, SC.
- 2
Dr. Abbass is in private practice in Beechwood, OH.