Trends in Genetics
LettersHomology between the mammalian liver and the Drosophila fat body
References (11)
Adv. Genet.
(1990)- et al.
Genes Dev.
(1992) Genes Dev.
(1992)Mol. Cell. Biol.
(1990)- et al.
Genetics
(1986)
Cited by (76)
The Precision Toxicology initiative
2023, Toxicology LettersRegulatory T cells as metabolic sensors
2022, ImmunityManipulating Mosquito Tolerance for Arbovirus Control
2019, Cell Host and MicrobeCitation Excerpt :Interestingly, CrebA-deficient flies are more likely to die from infection despite carrying the same number of bacteria as wildtype flies. CrebA is expressed in the fat body, an organ analogous to the mammalian liver and adipose tissues (Søndergaard, 1993), where it regulates the transcription of multiple secretory pathway genes. Loss of CrebA during infection triggers endoplasmic reticulum stress, which is sufficient to sensitize flies to infection.
Two faces of PPARα/NFκB signaling pathway in inflammatory responses to adipocytes lipolysis in grass carp Ctenopharyngodon idella
2019, Fish and Shellfish ImmunologyTransferrin 1 Functions in Iron Trafficking and Genetically Interacts with Ferritin in Drosophila melanogaster
2019, Cell ReportsCitation Excerpt :Tsf1 expression in response to iron suggests that Tsf1 could be responsible for iron uptake, as is seen with mammalian TF (Anderson and Vulpe, 2009). Because Tsf1 appears to function in the fat body, a tissue that is analogous to the mammalian liver (Baker and Thummel, 2007; Leopold and Perrimon, 2007; Søndergaard, 1993; Gutierrez et al., 2007) (Figure 1F), we decided to investigate the role of fat body-derived Tsf1 in iron homeostasis. We adopted the UAS/GAL4 system to knock down Tsf1 expression specifically in the fat body by crossing Tsf1 RNAi flies to the fat body-specific driver Cg-GAL4 (Pastor-Pareja and Xu, 2011).