Elsevier

Regulatory Peptides

Volume 20, Issue 2, February 1988, Pages 171-180
Regulatory Peptides

[Arg3]substance P and neurokinin A from chicken small intestine

https://doi.org/10.1016/0167-0115(88)90050-XGet rights and content

Abstract

Using antisera specific for NH2-terminal and COOH-terminal regions of substance P and for the COOH-terminal region of neurokinin A, peptides with tachykinin-like immunoreactivity were isolated from extracts of chicken small intestine. The peptide Arg-Pro-Arg-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 differs from human substance P by substitution of the lysyl residue by an arginyl residue at position 3. Synthetic [Arg3]substance P showed identical chromatographic and immunochemical properties to chicken substance P and was equipotent with substance P in contracting the guinea pig ileum. A second peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2 isolated from the extracts is identical to human neurokinin A. A third peptide was immunoreactive towards the COOH-terminally directed antiserum to substance P only but was not characterized structurally in this study.

References (30)

Cited by (26)

  • Overviews of avian neuropeptides and peptides

    2022, Sturkie's Avian Physiology
  • Evolution of vertebrate neuropeptides

    2001, Brain Research Bulletin
View all citing articles on Scopus
View full text