Isolation, purification, and partial characterization of prunellin, an anti-HIV component from aqueous extracts of Prunella vulgaris
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In vivo hepatoprotective potential of extracts obtained from floral spikes of Prunella vulgaris L
2020, Journal of Ayurveda and Integrative MedicinePotential of selected Lamiaceae plants in anti(retro)viral therapy
2018, Pharmacological ResearchCitation Excerpt :This is not the only polysaccharide with detected anti-HIV properties. Investigating inflorescence of self-heal, researchers were able to isolate sulfated polysaccharide named prunellin, with excellent activity against HIV, without detected cytotoxicity [54,98]. Furthermore, various active compounds were isolated from different representatives of genus Salvia and tested for antiviral properties.
Structural characterization and antiviral effect of a novel polysaccharide PSP-2B from Prunellae Spica
2016, Carbohydrate PolymersCitation Excerpt :PS has also been utilized clinically to treat high blood pressure, breast hyperplasia, hyperthyrea, and herpetic keratitis (Cui & Miao, 2014; Gao & Dong, 2003; Yang, Guo, Wu, Ye, & Xia, 2007). Phytochemical studies have illustrated that PS is rich in triterpenoids (Kojima & Ogura, 1986; Ryu et al., 2000), polysaccharides (Dore et al., 2013; Tabba, Chang, & Smith, 1989; Xu, Lee, Lee, White, & Blay, 1999), phenolic acids (Liu, 2010), flavonoids (Cheung & Zhang, 2008; Ye, 2010) and steroids (Kojima, Sato, Hatano, & Ogura, 1990). Pharmacological investigations have also indicated that the crude aqueous extract of PS has immunostimulatory, antioxidant, anti-inflammatory, antitumor and antiviral activities (Choi et al., 2010; Han et al., 2009; Tabba et al., 1989; Xu et al., 1999).
Phytochemistry and pharmacological activities of the genus Prunella
2016, Food ChemistryCitation Excerpt :The anti-HIV effect of P. vulgaris water extract occurs mainly during the early interference and late viral binding events (Oh, Price, Brindley, et al., 2011), by inhibiting recombinant HIV-1 reverse transcriptase activity, with ID50 of 26.0 μg/ml (Collins, Ng, Fong, Wan, & Yeung, 1997). A sulfur-containing anionic polysaccharide-prunellin with a molecular weight of 10 kDa isolated from the water extract of P. vulgaris showed the ability to block HIV-1 from entering cells (Tabba et al., 1989). Some studies reported that the major anti-HIV-1 effective substance was tannins of P. vulgaris and that they worked by inhibiting HIV-1 integrase activity (Au, Lam, Ng, Fong, & Wan, 2001), as well as inhibiting the formation of the six-helix bundle of HIV-1 gp41 protein (Liu et al., 2002) and the recombinant HIV-1 protease activity (Lam et al., 2000).