Receptor sites for Ca2+ channel antagonists

doi:10.1016/0165-6147(92)90079-L

Trends in Pharmacological Sciences

Volume 13, 1992, Pages 256-262

https://doi.org/10.1016/0165-6147(92)90079-L Get rights and content

Abstract

Ca²⁺ channel antagonist drugs inhibit voltage-gated Ca²⁺ channels in many different cell types. Inhibition of Ca²⁺ channels in smooth muscle and cardiac muscle cells by these drugs is valuable in the therapy of a wide range of cardiovascular disorders including hypertension, atrial arrhythmia and angina pectoris. Additional uses under evaluation are protection against ischemic damage during myocardial infarction and stroke and in a wide range of other conditions. Further understanding of the sites and mechanisms of action of Ca²⁺ channel antagonists, as described in this review by Bill Catterall and Jörg Striessnig, will provide new insight into the design of novel therapeutic agents acting on Ca²⁺ channels and provide further understanding of Ca²⁺ channel structure and function.

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Trends in Pharmacological Sciences

Receptor sites for Ca2+ channel antagonists

Abstract

Trends Pharmacol. Sci.

J. Mol. Cell. Cardiol.

FEBS Lett.

J. Biol. Chem.

J. Biol. Chem.

J. Biol. Chem.

Trends Biochem. Sci.

J. Biol. Chem.

Neuron

J. Biol. Chem.

J. Biol. Chem.

Annu. Rev. Pharmacol. Toxicol.

Nature

Pflugers Arch.

Annu. Rev. Pharmacol. Toxicol.

Nature

J. Gen. Physiol.

Receptor sites for Ca²⁺ channel antagonists