Immunovascular communication: activation and deactivation of murine endothelial cell nitric oxide synthase by cytokines
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Cited by (32)
The intriguing role of polymorphonuclear neutrophils in antitumor reactions
2001, BloodCitation Excerpt :This expression and subsequent intratumoral accumulation of PMNs were directly attributable to IL-10, since no secondary mediators were detected.35,36 Moreover, it is likely that IL-10 attenuates the constitutive endothelial cell release of nitric oxide37 and contributes to the adhesion of PMNs to microvessels38,39 and their intratumoral accumulation. It has been recently reported that IL-10 up-regulates the expression of the liver-expressed chemokine (LEC), a human β chemokine also known as NCC-4, HCC-4, and LMC.40
Endobronchial transfection of naked viral interleukin-10 gene in rat lung allotransplantation
2001, Annals of Thoracic SurgeryCitation Excerpt :Several studies that support our results of iNOS suppression by IL-10 have been reported. IL-10 was found to inhibit the induction of iNOS in endothelial cells by cytokines [33]. There are also some in vivo indications that IL-10 counteracts an excessive production of NO. For instance, gene transfer of IL-10 cDNA in mice results in a protective effect against lethal endotoxemia, of which NO is an important component [34].
Nitric oxide synthase expression and nitric oxide production are reduced in hypertrophic scar tissue and fibroblasts
1997, Journal of Investigative Dermatology