Elsevier

Psychiatry Research

Volume 36, Issue 3, March 1991, Pages 265-277
Psychiatry Research

Sleep, depression, and suicide

https://doi.org/10.1016/0165-1781(91)90025-KGet rights and content

Abstract

In a retrospective study of the electroencephalographic (EEG) sleep of major depressives with and without a history of suicide attempts, suicide attempters had longer sleep latency, lower sleep efficiency, and fewer late-night delta wave counts than normal controls. Nonattempters, compared to attempters, had less rapid eye movement (REM) time and activity in period 2, but more delta wave counts in non-REM period 4. Although both attempters and nonattempters were like controls in regard to REM period 2, patients with suicide attempts had altered intranight temporal distribution of phasic REM activity, with increased REM activity (by both visual and automated scoring) in REM sleep period 2 (significant group × period interaction). These findings, which may be more traitlike or persistent than state-related, are discussed in the context of current theories on the role of serotonin in the regulation of sleep and in suicidal behavior.

References (33)

  • R.A. Depue et al.

    Conceptualizing a serotonin trait: A behavioral dimension of constraint

  • J.M. Gaillard

    Biochemical pharmacology of paradoxical sleep

    British Journal of Clinical Pharmacology

    (1983)
  • J.M. Gaillard

    Neurochemical regulation of the states of alertness

    Annals of Clinical Research

    (1985)
  • C.F.P. George et al.

    The effects of L-tryptophan on daytime sleep latency in normals: Correlation with blood levels

    Sleep

    (1989)
  • M. Hamilton

    A rating scale for depression

    Journal of Neurology, Neurosurgery and Psychiatry

    (1960)
  • J.A. Hobson

    The neurology of sleep

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    Erin Sabo, M.D., is a Psychiatric Resident; Charles F. Reynolds III, M.D., is Professor; David J. Kupfer, M.D., is Professor and Chairman; and Susan R. Berman, B.A., is Data Manager, Department of Psychiatry, University of Pittsburgh School of Medicine.

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