Endogenous opiates increase pain tolerance after stress in humans
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Cited by (39)
Stress-induced modulation of pain: Role of the endogenous opioid system
2018, Progress in Brain ResearchCitation Excerpt :The increase in pain threshold but not tolerance was reversed by naloxone indicating a role of the opioid system in conditioned SIA in humans. In addition, healthy volunteers exhibited naloxone-reversible unconditioned SIA to electric shock-evoked pain, while their limbs were exposed to ice-cold water (Jungkunz et al., 1983; Robertson et al., 2008). In contrast, Pertovaara et al. (1982) showed that naloxone did not affect the elevated dental pain threshold induced by peripheral electrical stimulation, though this discrepancy could be due to the administration of naloxone at a low dose.
Top-down attentional modulation of analgesia induced by heterotopic noxious counterstimulation
2012, PainCitation Excerpt :Heterotopic noxious counterstimulation (HNCS) by the application of a sustained noxious stimulus has been shown to inhibit nociceptive processes and decrease subjective pain ratings induced by a competing noxious stimulus [11,21,30,35,40,48,49] (see also [5] for review).
Cold-induced limb pain decreases sensitivity to pressure-pain sensations in the ipsilateral forehead
2009, European Journal of PainCitation Excerpt :It is thus likely that stress-induced analgesia contributed to the bilateral forehead analgesia. Indeed, endogenous opioids have been found to be partly involved in the analgesia following cold water-induced limb pain (Jungkunz et al., 1983; Robertson et al., 2008). In the present study, higher distress ratings were associated with greater forehead analgesia to pressure but not sharpness.
Stress-evoked opioid release inhibits pain in major depressive disorder
2008, PainCitation Excerpt :Opioid analgesia has been identified in a diverse range of animal models, characterized by lack of control over aversive stimuli such as cold-water immersion, electric shocks, and centrifugal rotation [1,41]. In human research, μ-opioid receptor blockade antagonized stress-induced analgesia evoked by noxious electric shocks [47,48], immersion of a limb in ice-water [28,40], the perception of failure on a difficult cognitive task [2,3,20], a combat video shown to Vietnam veterans with post-traumatic stress disorder [38], and a first-time parachute jump [27]. Effects of μ-opioid receptor blockade on experimental pain are more variable [16,23,40], possibly because of individual differences in sensitivity to or release of opioid peptides.
The Effect of Subcutaneous Naloxone on Experimentally Induced Pain
2008, Journal of PainCitation Excerpt :In animal studies, central opioid-mediated analgesia develops during prolonged stress,10 particularly when the stress is inescapable.5,19 Similarly, experimentally induced stress evokes opioid analgesia in healthy humans,3,20,41-43 and may have induced a similar response during lengthy immersions in the present study. Alternatively, naloxone may have acted peripherally on opioid receptors in the nonimmersed hand.