VIEWPOINTNon-paternity and prenatal genetic screening
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Cited by (100)
Maternal carrier screening with single-gene NIPS provides accurate fetal risk assessments for recessive conditions
2023, Genetics in MedicineCitation Excerpt :In a hypothetical scenario with 0% misattributed paternity and 100% paternal screening uptake, traditional carrier screening has an end-to-end sensitivity of 93% to identify an HRC and therefore increased risk for an affected pregnancy, based solely on the multiplication of sensitivity of carrier screening for 2 parents (Figure 3).5 In a best-case scenario with 100% paternal screening uptake but misattributed paternity in 10% of cases5,6 (causing erroneous fetal risk assessments), the end-to-end sensitivity drops to 84%. In a US-average, real-world scenario in which paternity may be misattributed in 10% of cases and paternal carrier screening may not be performed in 58%2,4 of cases, the end-to-end sensitivity further drops to 35% (Figure 3).
Molecular insights into the divergence and diversity of post-testicular maturation strategies
2020, Molecular and Cellular EndocrinologyLow nonpaternity rate in an old Afrikaner family
2012, Evolution and Human BehaviorTime to exorcise the cloning demon
2014, Cambridge Quarterly of Healthcare Ethics