Elsevier

The Lancet

Volume 338, Issue 8771, 5 October 1991, Pages 869-871
The Lancet

VIEWPOINT
Non-paternity and prenatal genetic screening

https://doi.org/10.1016/0140-6736(91)91513-TGet rights and content

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Cited by (100)

  • Maternal carrier screening with single-gene NIPS provides accurate fetal risk assessments for recessive conditions

    2023, Genetics in Medicine
    Citation Excerpt :

    In a hypothetical scenario with 0% misattributed paternity and 100% paternal screening uptake, traditional carrier screening has an end-to-end sensitivity of 93% to identify an HRC and therefore increased risk for an affected pregnancy, based solely on the multiplication of sensitivity of carrier screening for 2 parents (Figure 3).5 In a best-case scenario with 100% paternal screening uptake but misattributed paternity in 10% of cases5,6 (causing erroneous fetal risk assessments), the end-to-end sensitivity drops to 84%. In a US-average, real-world scenario in which paternity may be misattributed in 10% of cases and paternal carrier screening may not be performed in 58%2,4 of cases, the end-to-end sensitivity further drops to 35% (Figure 3).

  • Low nonpaternity rate in an old Afrikaner family

    2012, Evolution and Human Behavior
  • Time to exorcise the cloning demon

    2014, Cambridge Quarterly of Healthcare Ethics
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