Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras

doi:10.1016/0092-8674(94)90513-4

Cell

Volume 76, Issue 4, 25 February 1994, Pages 747-760

https://doi.org/10.1016/0092-8674(94)90513-4 Get rights and content

Abstract

As NIH 3T3 fibroblasts become quiescent, the level of c-Jun protein decreases while JunD accumulates. When resting cells are stimulated with fresh serum, nuclear-localized JunD is rapidly degraded, followed by resynthesis of both c-Jun and JunD later in G1. Overexpression of JunD results in slower growth and an increase in the percentage of cells in $G0 G1$ while c-Jun overexpression produces larger $S G2$ and M phase populations. In addition, JunD partially suppresses transformation by an activated ras gene whereas c-Jun cooperates with ras to transform cells. These data indicate that two clsely related transcription factors can function in an opposing manner.

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^†: The first two authors contributed equally to this work.

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Cell

ArticleMouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras

Abstract

Biochim. Biophys. Acta

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Cell

Cell

Cell

Cell

Biochimie

Cell

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Cell

Cell

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Gene

Adv. Cancer Res.

Cell

Cell

Complexity of the early genetic response to growth factors in mouse fibroblasts

Mol. Cell. Biol.

12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5′-flanking region

Mol. Cell. Biol.

Jun and v-Jun contain multiple regions that participate in transcriptional activation in an independent manner

New Biol.

IkB: a specific inhibitor of the NF-kB transcription factor

Science

ras genes

Annu. Rev. Biochem.

Heterodimer formation between CREB and JUN proteins

Oncogene

Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

Nature

Regulators and effectors of ras proteins

Annu. Rev. Cell Biol.

Efficient transformation of chicken embryo fibroblasts by c-Jun requires structural modification in coding and noncoding sequences

Genes Dev.

Transcription factors JunB and c-Jun are selectively up-regulated and functionally implicated in fibrosarcoma development

Genes Dev.

Overexpression of c-jun, junB, or junD affects cell growth differently

Article
Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras