The three-dimensional structure of the tenth type III module of fibronectin: An insight into RGD-mediated interactions

doi:10.1016/0092-8674(92)90600-H

Cell

Volume 71, Issue 4, 13 November 1992, Pages 671-678

https://doi.org/10.1016/0092-8674(92)90600-H Get rights and content

Abstract

The solution structure of the tenth type III module of fibronectin has been determined using nuclear magetic resonance techniques. The molecule has a fold similar to that of immunoglobulin domains, with seven β strands forming two antiparallel β sheets, which pack against each other. Both β sheets contribute conserved hydrophobic residues to a compact core. The topology is more similar to that of domain 2 of CD4, PapD, and the extracellular domain of the human growth hormone receptor than to that of immunoglobulin C domains. The module contains an Arg-Gly-Asp sequence known to be involved in cell adhesion. This tripeptide is solvent exposed and lies on a conformationally mobile loop between strands F and G, consistent with its cell adhesion function.

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^†: Present address: Boyer Center for Molecular Medicine, Yale University School of Medicine, 295 Congress Avenue, New Haven, Connecticut 06536.

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Cell

ArticleThe three-dimensional structure of the tenth type III module of fibronectin: An insight into RGD-mediated interactions

Abstract

J. Biol. Chem.

Trends Biochem. Sci.

Meth. Enzymol.

J. Mol. Biol.

J. Magn. Reson.

Meth. Enzymol.

J. Mol. Biol.

Trends Biochem. Sci.

J. Mol. Biol.

Cell

J. Magn. Reson.

J. Magn. Reson.

J. Magn. Reson.

Cell

Curr. Opin. Struct. Biol.

J. Mol. Biol.

J. Biol. Chem.

J. Biol. Chem.

Solution structure of kistrin, a potent platelet aggregation inhibitor and GPIIb-IIIa antagonist

Science

Structure of the fibronectin type 1 module

Nature

1H NMR assignment and secondary structure of the cell adhesion type III module of fibronectin

Biochemistry

Structural design and molecular evolution of a cytokine receptor superfamily

CHARMm: a program for macromolecular energy, minimization, and dynamic calculations

J. Comput. Chem.

Refined solution structure and ligand-binding properties of PDC-109 domain b: a collagen-binding type II domain

Biochemistry

Assignment of complex 1H n.m.r. spectra via two-dimensional homonuclear Hartmann-Hahn spectroscopy

J. Am. Chem. Soc.

Article
The three-dimensional structure of the tenth type III module of fibronectin: An insight into RGD-mediated interactions

¹H NMR assignment and secondary structure of the cell adhesion type III module of fibronectin

Assignment of complex ¹H n.m.r. spectra via two-dimensional homonuclear Hartmann-Hahn spectroscopy