Differential effects of mesocortical, mesolimbic, and mesostriatal dopamine depletion on spontaneous, conditioned, and drug-induced locomotor activity

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Abstract

Groups of rats with 6-hydroxydopamine (6-OHDA) lesions of either the medial prefrontal cortex (PFC), nucleus accumbens (NAC), or caudate putamen (CPu) were given daily tests for locomotor activity in photocell cages while food deprived. Two separate groups of NAC-lesioned rats were prepared with either large [NACT (90% NAC dopamine depletion)] or partial [NACP (67% NAC dopamine depletion)] lesions. NACT rats were spontaneously hypoactive whereas NACP rats were hyperactive compared with sham-operated controls. PFC-lesioned rats were also hyperactive compared to their respective controls. Spontaneous locomotor activity in CPu-lesioned rats did not differ from shams. When daily food supplements were paired with the photocell cages, all subjects developed a conditioned locomotor response. During the first few days of conditioning, the response to this conditioning procedure was markedly greater in the NACP group whereas the response in the NACT group was unaffected initially and actually enhanced during the latter days of testing. the locomotor response to the conditioning procedure was unaffected in either the PFC- or CPu-lesioned groups. Both the NACT and NACP lesions attenuated the locomotor response to 1.5 mg/kg d-amphetamine sulphate IP, and the NACT group showed a supersensitive response to 0.1 mg/kg apomorphine HCl SC. PFC or CPu 6-OHDA lesions did not alter the response to either drug. These results differentiate the role of PFC, NAC, and CPu dopamine in spontaneous, conditioned, and drug-induced locomotor activity and further implicate dopaminergic mechanisms of the NAC in the magnitude of the behavioral response to incentive stimuli.

References (68)

  • P.H. Kelly et al.

    Selective 6-OHDA-induced destruction of mesolimbic dopamine neurons: Abolition of psychomotor stimulant-induced locomotor activity in rats

    Eur. J. Pharmacol.

    (1976)
  • P.H. Kelly et al.

    Specificity of 6-hydroxydopamine-induced destruction of mesolimbic or nigrostriatal dopamine-containing terminals

    Brain Res.

    (1977)
  • P.H. Kelly et al.

    Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum

    Brain Res.

    (1975)
  • G.F. Koob et al.

    Hyperactivity and hypoactivity produced by lesions to the mesolimbic dopamine system

    Behav. Brain Res.

    (1981)
  • T. Ljungberg et al.

    Automatic registration of behaviour related to dopamine and noradrenaline transmission

    Eur. J. Pharmacol.

    (1976)
  • M. Papp et al.

    Separation of the motivational and motor consequences of 6-hydroxydopamine lesions of the mesolimbic or nigrostriatal system in rats

    Behav. Brain Res.

    (1987)
  • J.G. Pfaus et al.

    Sexual behavior enhances central dopamine transmission in the male rat

    Brain Res.

    (1990)
  • M. Reibaud et al.

    Non-dopamine prefronto-cortical efferents modulate D1 receptors in the nucleus accumbens

    Brain Res.

    (1984)
  • T.W. Robbins et al.

    Functional studies of the central catecholamines

    Int. Rev. Neurobiol.

    (1982)
  • T. Schallert et al.

    Cholecystokinin-octapeptide effects on eating elicited by ‘external’ versus ‘internal’ cues in rats

    Appetite

    (1982)
  • C. Spyraki et al.

    Dopaminergic substrates of amphetamine-induced place preference conditioning

    Brain Res.

    (1982)
  • K. Taghzouti et al.

    Behavioural study after local injection of 6-hydroxydopamine into the nucleus accumbens in the rat

    Brain Res.

    (1985)
  • J.-P. Tassin et al.

    Relationship between the locomotor hyperactivity induced by A10 lesions and the destruction of the fronto-cortical dopaminergic innervation in the rat

    Brain Res.

    (1978)
  • P. Winn et al.

    Comparative effects of infusions of 6-hydroxydopamine into nucleus accumbens and anterolateral hypothalamus on the response to dopamine agonists, body weight, locomotor activity and measures of exploration in the rat

    Neuropharmacology

    (1985)
  • A. Amsel et al.

    Activity during and between periods of stimulus change related to feeding

    J. Comp. Physiol. Pyschol.

    (1962)
  • D. Bindra

    Neuropsychological interpretation of the effects of drive and incentive motivation on general activity and instrumental behaviour

    Psychol. Rev.

    (1968)
  • J.R. Blackburn et al.

    Dopamine and preparatory behaviour: I. Effects of pimozide

    Behav. Neurosci.

    (1987)
  • J.R. Blackburn et al.

    Dopamine and preparatory behaviour: II. A neurochemical analysis

    Behav. Neurosci.

    (1989)
  • R.C. Bolles

    Theory of motivation

    (1967)
  • R.C. Bolles

    Reinforcement, expectancy, and learning

    Psychol. Rev.

    (1972)
  • R.C. Bolles et al.

    Derived motives

    Annu. Rev. Psychol.

    (1973)
  • R.C. Bolles et al.

    Rat's anticipation of diurnal and a-diurnal feeding

    J. Comp. Physiol. Psychol.

    (1965)
  • G.R. Breese et al.

    Depletion of brain norepinephrine and dopamine by 6-hydroxydopamine

    Br. J. Pharmacol.

    (1971)
  • B.A. Campbell et al.

    Relation of random activity to food deprivation

    J. Comp. Physiol. Psychol.

    (1953)
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