8-OH-DPAT suppresses vomiting in the cat elicited by motion, cisplatin or xylazine,☆☆

https://doi.org/10.1016/0091-3057(89)90399-7Get rights and content

Abstract

Vomiting was suppressed in cats pretreated with 8-OH-DPAT and then challenged with an emetic stimulus; motion, xylazine or cisplatin. The antiemetic effect is likely due to stimulation of postsynaptic serotonin-1A receptors. The most parsimonious explanation is that it acts at a convergent structure, presumably at or near the vomiting center. If so, 8-OH-DPAT may block emesis elicited by virtually any other stimulus. A supplementary experiment revealed that lorazepam suppressed motion sickness at a dose that produced ataxia, but did not suppress xylazine-induced emesis. These results do not support the possibility that the antiemetic effects of 8-OH-DPAT were the result of anxiolytic activity.

References (40)

  • A.D. Miller et al.

    ‘Vomiting center’ reanalyzed: An electrical stimulation study

    Brain Res.

    (1983)
  • S.J. Peroutka

    Selective interaction of novel anxiolytics with 5-hydroxytryptamine1A receptors

    Biol. Psychiatry

    (1985)
  • A. Robertson et al.

    Opposite effects of sulpiride and metoclopramide on amphetamine-induced stereotypy

    Eur. J. Pharmacol.

    (1985)
  • M.E. Trulson et al.

    Raphe unit activity in freely moving cats: Effects of benzodiazepines

    Neuropharmacology

    (1982)
  • M.E. Trulson et al.

    Buspirone decreases the activity of serotonin-containing neurons in the dorsal raphe in freely-moving cats

    Neuropharmacology

    (1986)
  • C.P. VanderMaelen et al.

    Inhibition of serotonergic dorsal raphe neurons by systemic and iontophoretic administration of buspirone, a non-benzodiazepine anxiolytic drug

    Eur. J. Pharmacol.

    (1986)
  • R. Andrade et al.

    The novel anxiolytic buspirone elicits a small hyperpolarization and reduces serotonin responses at putative 5-HT1 receptors on hippocampal CA1 pyramidal cells

    Soc. Neurosci. Abstr.

    (1985)
  • J.F. Bishop et al.

    Lorazepam: A randomized, double-blind, crossover study of a new antiemetic in patients receiving cytotoxic chemotherapy and prochlorperazine

    J. Clin. Oncol.

    (1984)
  • H.L. Borison et al.

    Functional localization of central coordinating mechanism for emesis in cat

    J. Neurophysiol.

    (1949)
  • W.G. Cochran

    The comparison of percentages in matched samples

    Biometrika

    (1950)
  • Cited by (0)

    Supported by Cooperative Agreement NCC2-229 between NASA-Ames Research Laboratory and Wright State University and a Research Challenge Grant from the State of Ohio allocated by Wright State University.

    ☆☆

    Portions of the data were presented at the International Symposium on Basic and Applied Aspects of Vestibular Function in Hong Kong, 1987, and the 17th annual meeting of The Society for Neuroscience.

    View full text