Elsevier

Human Pathology

Volume 23, Issue 6, June 1992, Pages 681-685
Human Pathology

Original contribution
Immunohistochemical study of epidermal growth factor and transforming growth factor-β in the penetrating type of early gastric cancer

https://doi.org/10.1016/0046-8177(92)90325-WGet rights and content

Abstract

We report that the penetrating type of early gastric cancer (PEN) is a specific type of early gastric cancer and that the poorly differentiated PEN type could be considered an initial lesion of linitis plastica-type cancer. We performed an immunohistochemical study to clarify the role of growth factors (epidermal growth factor [EGF] and transforming growth factor-β [TGF-β]) in the PEN type of early gastric cancer. The results indicated that the PEN type of early gastric cancer has a high growth capacity. Moreover, it was suggested that EGF was involved in its specific infiltrative growth and that both EGF and TGF-β were involved in its specific scirrhous growth. From these findings, it was assumed that the immunohistochemical staining of EGF and TGF-β in endoscopic biopsy specimens was useful for the diagnosis of the PEN type of gastric cancer and also for the diagnosis of the initial lesion of linitis plastica-type gastric cancer.

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