Elsevier

Cell Differentiation

Volume 8, Issue 3, June 1979, Pages 243-252
Cell Differentiation

Differentiation without mitosis in Dictyostelium discoideum

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Abstract

Dictyoselium discoideum Ax-2 amoebae incubated in the presence of the microtubule inhibitor nocodazole, irreversibly lost their ability to multiply. Nocodazole-treated cells remained viable and RNA and protein synthesis continued for at least 48 h. When nocodazole-treated amoebae were allowed to develop on Millipore filters or on agar slides they differentiated with some delay when compared with controls. These results show that mitosis, naturally present during the developmental cycle of Dictyostelium discoideum Ax-2, is not indispensible for differentiation.

References (24)

  • P. Cappuccinelli et al.

    Exp. Cell Res.

    (1976)
  • P. Cappuccinelli et al.

    FEBS Lett.

    (1978)
  • E.R. Katz et al.

    Develop. Biol.

    (1974)
  • W.F. Loomis

    Exp. Cell Res.

    (1971)
  • T.L. Shininger

    Dev. Biol.

    (1975)
  • M. Sussman
  • I. Zada-Hames et al.

    Develop. Biol.

    (1978)
  • J.T. Bonner

    The Cellular Slime Moulds

    (1969)
  • J.T. Bonner et al.

    J. Exp. Zool.

    (1952)
  • P. Cappuccinelli et al.

    Biochem. J.

    (1978)
  • P. Cappuccinelli et al.

    FEMS Microbiol. Letters

    (1978)
  • N.R. Cozzarelli

    Annu. Rev. Biochem.

    (1977)
  • Cited by (0)

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