NoteHandedness in women with intrauterine exposure to diethylstilbestrol
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Cited by (44)
An examination of the influence of prenatal sex hormones on handedness: Literature review and amniotic fluid data
2021, Hormones and BehaviorCitation Excerpt :However, whereas much circulating estradiol is rendered inactive due to being bound to other chemicals in the blood, DES is not, which allows it to cross the blood-brain barrier and, potentially, to exert masculinising effects on the brain without first having to be metabolised. Consistent with GBG or the sexual differentiation hypothesis, a study of 77 daughters of women administered DES (Geschwind and Galaburda, 1985b, p. 545; Schachter, 1994) found the handedness distribution to be shifted away from strong right preference in comparison to controls. A similar observation was made for 175 Dutch women (Scheirs and Vingerhoets, 1995), and a third study (Smith and Hines, 2000) found increased left hand preference for writing (but not for overall handedness on an 18-item inventory) as well as increased strength of hand preference (regardless of direction).
Beyond the genome—Towards an epigenetic understanding of handedness ontogenesis
2017, Progress in NeurobiologyCitation Excerpt :DES had been prescribed to pregnant women in prevention of birth complications until it was disadvised in 1971 due to massive side effects (Reed and Fenton, 2013). The distribution of handedness was significantly shifted to the left in women exposed to DES in utero when compared to controls in several studies (Schachter, 1994; Scheirs and Vingerhoets, 1995; Smith and Hines, 2000). Since prenatal testosterone passes between twins, fetuses having male co-twins should be exposed to higher levels of testosterone in their intrauterine environment than fetuses with female co-twins.
Second to fourth digit ratio, handedness and testicular germ cell tumors
2013, Early Human DevelopmentSex-specific effects of maternal testosterone on lateralization in a cichlid fish
2012, Animal BehaviourSteroid 21 Hydroxylase Deficiency Congenital Adrenal Hyperplasia
2011, Pediatric Clinics of North AmericaDecreased prevalence of left-handedness among females with male co-twins: Evidence suggesting prenatal testosterone transfer in humans?
2010, PsychoneuroendocrinologyCitation Excerpt :Another study of 65 women found significantly more left-handed writers among DES exposed subjects (17.5%) compared to unexposed subjects (4%) and further indicated that the exposure to DES before week nine of gestation was related to left-handedness (Smith and Hines, 2000). Also, one study found that 77 DES exposed women exhibited weaker right-handedness, measured with the Edinburgh Handedness Inventory, than 514 women who were not exposed to DES but there was no difference between these two groups of women when the comparison was made by using the laterality score of zero as a cutpoint (Schachter, 1994). In animals, prenatal transfer of testosterone occurs between foetuses, and it has been shown that females adjacent to males in their uterine environment can be prenatally masculinised by testosterone exposure (Ryan and Vandenbergh, 2002).