The actions of fentanyl to inhibit drug-induced emesis
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Further investigation of the rapid-onset and short-duration action of the G protein-biased μ-ligand oliceridine
2021, Biochemical and Biophysical Research CommunicationsCitation Excerpt :This background clearly indicates that the ability to cross the blood-brain barrier, namely the rapid onset of action induced by oliceridine, may be related to a low inducibility for constipation induced by μ-opioid receptor agonists. It has been demonstrated that fentanyl induced respiratory depression without inducing retching or vomiting in ferrets as observed in previous study [27] with unpublished observation. In contrast, although oliceridine produced retching and vomiting, it was less effective at inducing emesis than morphine, as demonstrated in our previous [17] and present studies.
Effects of naloxone on motion sickness in cats alone and with broad spectrum antiemetics
2017, Autonomic Neuroscience: Basic and ClinicalCitation Excerpt :Nausea and ANS symptoms usually precede vomiting but either may consistently occur before the other and the ANS symptoms are consistently either sympathetic or parasympathetic (Cowings et al., 1990). To date, the opioids are the only drug class in clinical practice that can prevent emesis by all stimuli, which is an action separate from their ability to elicit emesis (Kakimoto et al., 1997; Barnes et al., 1991; Costello and Borison, 1977). This suggests that the relevant receptors are at some critical level of emetic pathway past those which carry the information from specific emetic stimuli.
Pathophysiological and neurochemical mechanisms of postoperative nausea and vomiting
2014, European Journal of PharmacologyCitation Excerpt :Whereas µ opioid receptors in the AP are involved in the activation of emesis, those in the NTS provide inhibitory effects on emesis. Fentanyl, a more lipophilic opioid agonist compared to morphine, demonstrates antiemetic properties; potentially because it quickly penetrates to µ opioid receptors located in the hindbrain (e.g., NTS) (Barnes et al., 1991). There is some suggestion that sub-types of µ receptors (µ1 and µ2) mediate the emetic and anti-emetic effects, although whether these findings from animal studies translate directly to humans remains to be established (see review Johnston, 2010).
Post-anesthesia vomiting: Impact of isoflurane and morphine on ferrets and musk shrews
2012, Physiology and BehaviorAnesthesia and Analgesia in Ferrets
2008, Anesthesia and Analgesia in Laboratory AnimalsIs there a need to identify new anti-emetic drugs?
2007, Drug Discovery Today: Therapeutic Strategies