Effects of high-intensity focused ultrasound in the treatment of experimental neuroblastoma☆,☆☆
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2020, Biochimica et Biophysica Acta - Reviews on CancerCitation Excerpt :HIFU improves the infiltration of innate and adaptive immune cells into destroyed tumor tissues. Both T- and M-HIFU increase the number and cytotoxicity of CTLs, resulting in improved survival of mice [46–49]. They also contribute to the infiltration of CD11c + DCs [37].
High-Intensity Focused Ultrasound– and Radiation Therapy–Induced Immuno-Modulation: Comparison and Potential Opportunities
2017, Ultrasound in Medicine and BiologyCitation Excerpt :Magnetic resonance–guided focused ultrasound surgery technology, which combines a HIFU beam and magnetic resonance imaging system, has the potential to locally achieve complete tumor cell destruction through thermal ablation, with great precision and minimal damage to adjacent tissues. By focusing a high-energy ultrasound beam to a well-defined target region, a local coagulative necrosis occurs due to the thermal dose released as the acoustic energy propagates through the focal tumor volume (Bastianpillai et al. 2015; ter Haar 1995; Wu et al. 2007a; Yang et al. 1992; Zhou 2011). Over the last 10 y, a growing number of clinical trials have examined HIFU treatment of both benign and malignant tumours of the liver, breast, pancreas, bone, connective tissue, thyroid, parathyroid, kidney and brain.
Drug Delivery to the Brain via Focused Ultrasound
2015, Image-Guided NeurosurgeryUltrasound induced cancer immunotherapy
2014, Advanced Drug Delivery ReviewsCitation Excerpt :Today HIFU has been applied in clinical studies to treat prostate cancer, breast cancer, kidney tumors, liver tumors, pancreas tumors and glioblastoma in the brain [46]. One of the early clues to the immune-stimulating potential of HIFU came from Yang and co-workers [47]. They treated mice with subcutaneous murine neuroblastoma C1300 with HIFU to ablate the tumors.
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Supported in part by American Cancer Society Institutional Grant No. 57-881-16, Atlanta, GA, and the Showalter Residuary Trust Fund, Indianapolis, IN.
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Presented at the 22nd Annual Meeting of the American Pediatric Surgical Association, Lake Buena Vista, Florida, May 15–18, 1991.