The impact of refugia on the development of thiabendazole resistance in Haemonchus contortus
References (17)
Egg hatch as an in vitro assay of thiabendazole resistance in nematodes
Veterinary Parasitology
(1976)Grazing management and control of parasites in sheep
- et al.
Some observations on asymmetrical correlated responses to selection
Genetic Research
(1966) - et al.
Anthelmintic activity of tetramisole, thiabendazole and purified fine particle phenothiazine against experimental infections of Haemonchus contortus and Trichostrongylus species in sheep
- et al.
Field studies on parasite control in sheep: comparison of thiabendazole, ruelene, and phenothiazine
American Journal of Veterinary Research
(1964) - et al.
Pesticide resistance as an evolutionary phenomenon
- et al.
Genetic and biological influences in the evolution of insecticide resistance
Journal of Economic Entomology
(1977) The interpretation of insecticide resistance in terms of changes in ratio of genotypes
Cited by (91)
A journey through 50 years of research relevant to the control of gastrointestinal nematodes in ruminant livestock and thoughts on future directions
2021, International Journal for ParasitologyCitation Excerpt :Where no parasites were in refugia, resistance increased rapidly; with increasing refugia, resistance was slower to develop. The refugia in this experiment consisted of worms given artificially to the housed animals after drug treatment, however, the outcome illustrated the concept of slowing resistance development through the uptake of susceptible larvae by animals on pasture following anthelmintic treatment (Martin et al., 1981). Where too few worms are likely to survive in the environment to provide an adequate population in refugia, “Targeted Selective Treatment” (TST) ensures that drenches are given specifically to individuals likely to suffer serious parasitism, allowing a proportion of a flock or herd to remain untreated (Leathwick and Besier, 2014).
Multiple drug resistance in hookworms infecting greyhound dogs in the USA
2021, International Journal for Parasitology: Drugs and Drug ResistanceSpread of anthelmintic resistance in intestinal helminths of dogs and cats is currently less pronounced than in ruminants and horses – Yet it is of major concern
2021, International Journal for Parasitology: Drugs and Drug ResistanceRefugia-Based Strategies for Parasite Control in Livestock
2020, Veterinary Clinics of North America - Food Animal PracticeManaging anthelmintic resistance in cyathostomin parasites: Investigating the benefits of refugia-based strategies
2019, International Journal for Parasitology: Drugs and Drug ResistanceCitation Excerpt :The concept of parasite refugia (van Wyk, 2001), which involves leaving a proportion of the worm population unexposed to anthelmintic treatment as a source of susceptible genes, has become a corner-stone of resistance management in grazing ruminants (Leathwick and Besier, 2014; Hodgkinson et al., 2019). Both modelling (Barnes et al., 1995; Leathwick, 2012) and experimental studies (Martin et al., 1981; Waghorn et al., 2008; Leathwick et al., 2006, 2012) have demonstrated the importance of retaining unexposed (susceptible) worm genotypes in refugia as a means of diluting the survivors of anthelmintic treatment and slowing the development of anthelmintic resistance. Numerous approaches to achieving this end have been developed and adopted to varying degrees around the world (reviewed by Hodgkinson et al., 2019).
Parasite Control Programs
2019, Large Animal Internal Medicine
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