Movement and extension of isolated growth cones
References (17)
- et al.
Exp cell res
(1960) - et al.
Exp cell res
(1972) Arch exp Zellforsch
(1926)J anat
(1953)- et al.
Z Zellforsch
(1968) J cell biol
(1973)- et al.
- et al.
Cited by (154)
Immediate elimination of injured white matter tissue achieves a rapid axonal growth across the severed spinal cord in adult rats
2018, Neuroscience ResearchCitation Excerpt :After a transection of the cord in adult mice, an in vivo imaging has shown that severed axons die back 200–300 μm from the lesion site within 30 min of surgery (Kerschensteiner et al., 2005). In addition, severed axons grow normally for 2–5 hours in the presence of protein synthesis inhibitor in culture (Shaw and Bray, 1977; Campbell and Holt, 2001; Leung et al., 2006), suggesting autonomy of initial axonal growth. As a calculation taking these into account, severed axons would start regrowth as early as 1 h after a cord section at 200 μm from the lesion site.
Mechanism of Axonal Contractility in Embryonic Drosophila Motor Neurons In Vivo
2016, Biophysical JournalCitation Excerpt :Contraction is also observed in neurites that are surgically severed. Earlier, Shaw et al. (12) described how isolated axon segments in vitro often shorten after they are resected. A number of in vitro studies have also demonstrated similar shortening behavior of axons upon surgical incision (13–15).
Manually-stimulated recovery of motor function after facial nerve injury requires intact sensory input
2008, Experimental NeurologyMechanosensitive Channels in Neurite Outgrowth
2007, Current Topics in MembranesCitation Excerpt :A variety of simultaneous environmental stimuli is likely to confront the growth cone that must therefore integrate inputs and choose an appropriate final response, consisting in a reorganization of cytoskeleton and adhesion complexes (Lin et al., 1994; Gomez and Zheng, 2006; Wen and Zheng, 2006). Both in vitro (Shaw and Bray, 1977) and in vivo (Harris et al., 1987) experiments demonstrate that individual growth cones are largely independent of cell body in their responses to environmental cues; accordingly, the essential components for extension and guidance are locally regulated (Ming et al., 2002). In the next section, a basic summary of current knowledge regarding the mechanisms of calcium‐dependent axon pathfindings will be provided.
Control of Selective mRNA Translation in Neuronal Subcellular Compartments in Health and Disease
2023, Journal of NeuroscienceAn experimental platform for stochastic analyses of single serotonergic fibers in the mouse brain
2023, Frontiers in Neuroscience