Rapid communicationActivation of glutamate metabotropic receptors induces long-term potentiation
References (6)
- et al.
1S,3R-ACPD stimulates and L-AP3 blocks Ca2+ mobilization in rat cerebellar neurons
Eur. J. Pharmacol.
(1990) - et al.
Trans-ACPD enhances long-term potentiation in the hippocampus
Eur. J. Pharmacol.
(1991) - et al.
Metabotropic receptor-mediated long-term potentiation in rat hippocampal slices
Eur. J. Pharmacol.
(1991)
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Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP
2005, NeuropharmacologyCitation Excerpt :These findings linking FMRP and mGluRs at the synapse build upon earlier evidence that both FMRP and mGluRs have important roles in synaptic plasticity. For example, absence of FMRP appears to negatively affect synaptic morphology in both humans and mice (Comery et al., 1997; Hinton et al., 1991; Irwin et al., 2001; Jenkins et al., 1984; Nimchinsky et al., 2001; Rudelli et al., 1985), while metabotropic glutamate receptors have a well known role in long-term synaptic plasticity, including induction of LTP in the hippocampus, and LTD at the parallel-Purkinje cell synapse of the cerebellum (Anwyl, 1999; Bashir et al., 1993; Bortolotto et al., 1994; Bortolotto and Collingridge, 1992; Linden, 1994; McGuinness et al., 1991; Zheng and Gallagher, 1992). Interestingly, DHPG stimulation has been demonstrated to produce elongated spines in cultured hippocampal neurons (Vanderklish and Edelman, 2002).
Characterization of modulatory effects of postsynaptic metabotropic glutamate receptors on calcium currents in rat nucleus tractus solitarius
2004, Brain ResearchCitation Excerpt :Furthermore, a number of signaling pathways modulated by the activation of mGluRs have been identified as contributing to long-lasting synaptic changes [11,67], neuroplasticity, neurotoxicity, neuromodulation [22,68], neurodegeneration, ischaemic brain damage, and epilepsy [22,65]. In synaptic regions, mGluRs have been shown to participate in the processes of synaptic plasticity, such as long-term potentiation [12,57] and long-term depression [45]. Long-term changes in synaptic efficacy involve Ca2+-dependent processes and therefore might also depend upon the presently observed coupling between mGluRs and VDCCs.
MGluRs regulate the expression of neuronal calcium sensor proteins NCS-1 and VILIP-1 and the immediate early gene arg3.1/arc in the hippocampus in vivo
2004, Biochemical and Biophysical Research CommunicationsCharacteristics of GABA release modified by glutamate receptors in mouse hippocampal slices
2003, Neurochemistry International