Effects of 5-HT1A receptor agonists and NMDA receptor antagonists in the social interaction test and the elevated plus maze
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Biased agonism in drug discovery: Is there a future for biased 5-HT<inf>1A</inf> receptor agonists in the treatment of neuropsychiatric diseases?
2021, Pharmacology and TherapeuticsCitation Excerpt :Many studies show 5-HT1A receptor agonists to possess anxiolytic-like properties (Lacivita, Leopoldo, Berardi, & Perrone, 2008). Administration of a 5-HT1A receptor agonists, 8-OH-DPAT, buspirone, and gepirone, induces anxiolytic-like effects in rodents, as shown in the elevated plus maze and the social interaction tests (Dunn, Corbett, & Fielding, 1989). However, buspirone has contrasting effects that are dose-dependent (Collinson & Dawson, 1997; Critchley, Njung'e, & Handley, 1992; Kostowski, Dyr, Krzascik, Järbe, & Archer, 1992), explained by its effects on both types of 5-HT1A receptors.
Differential expression of glutamatergic receptor subunits in the hippocampus in carioca high- and low-conditioned freezing rats
2021, Molecular and Cellular NeuroscienceThe effect of 5-HT<inf>4</inf> serotonin receptors in the CA3 hippocampal region on D-AP5-induced anxiolytic-like effects: Isobolographic analyses
2021, Behavioural Brain ResearchCitation Excerpt :Despite the fact that NMDA receptor density is high in cortical and limbic regions which are involved in anxiety, such as prefrontal cortex, amygdala, and hippocampus, a wide distribution throughout the brain regions can happen by both ionotropic and metabotropic glutamate receptors [8,9]. Several studies have reported the anxiolytic-like effect of NMDA receptors blockade; for example, D-AP5 (D-[−]-2-amino-5-phosphonopentanoic acid) and D-AP7 (D-[−]-2-amino-7-phosphonopentanoic acid), two competitive NMDA receptor antagonists, can decrease anxiety-related behaviors in rats [10,11]. It has been indicated that D-AP5 can induce anxiolytic, antidepressant, and antinociceptive effects [12–14].
Fear-context association during memory retrieval requires input from granular to dysgranular retrosplenial cortex
2019, Neurobiology of Learning and Memory