Elsevier

Clinica Chimica Acta

Volume 67, Issue 2, 1 March 1976, Pages 131-136
Clinica Chimica Acta

Increased urinary excretion of l-xylulose in patients with liver cirrhosis

https://doi.org/10.1016/0009-8981(76)90251-5Get rights and content

Abstract

The urinary excretions of l-xylulose, xylitol and d-glucarate after the oral administration of glucuronolactone (5 g) were measured in normal healthy persons, patients with diabetes mellitus, acute hepatitis in recovery stage, chronic hepatitis and liver cirrhosis. In normal subjects, the mean value of l-xylulose excretion was 14.6 ± 1.4 μmol/2 h with a range from 6.5 to 21.8. Marked increase of l-xylulose excretion was observed in cirrhotic patients, the mean value was 97.1 ± 19.8 with a range from 22.0 to 236.6. Though some cases of acute and chronic hepatitis showed higher values than the normal range, no case exceeded 50 μmol/2 h. The urinaory excretion of xylitol in cirrhotic patients was also higher than normal and no increase was observed in d-glucarate excretion. The values of l-xylulose excretion in cirrhosis were correlated with the values of serum total bilirubin, albumin, albumin/globulin ratio, lactate dehydrogenase and prothrombin time. These findings indicate that the measurement of l-xylulose in urine after the oral glucuronolactone loading provides a useful tool for evaluation of the severity of liver cirrhosis.

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