Increased urinary excretion of l-xylulose in patients with liver cirrhosis
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Cited by (16)
Characterization of xylitol 4-dehydrogenase from Erwinia aphidicola and its co-expression with NADH oxidase in Bacillus subtilis
2021, Process BiochemistryCitation Excerpt :This rare sugar has potential applications in the pharmaceutical and food industries as an anti-cancer and antiviral drug [5], an immunosuppressant [6], and as a low-calorie sweetener [7]. As an inhibitor of α-glucosidase, l-xylulose can effectively reduce the level of blood glucose in diabetic patients [8,9]. In addition, it can be used as a precursor to produce other rare sugars, such as α-ribose and β-xylose, which contribute to the production of antiviral drugs [1,10].
A urinary metabolomics study of a Polish subpopulation environmentally exposed to arsenic
2019, Journal of Trace Elements in Medicine and BiologyCitation Excerpt :Urinary excretions of L-threo-2-pentulose (L-xylulose) after oral administration of glucuronolactone were measured in normal healthy individuals and in patients with diabetes mellitus, acute hepatitis in a recovery stage, chronic hepatitis and liver cirrhosis. A marked increase in L-xylulose excretion has been observed in cirrhotic, acute and chronic hepatitis patients compared to the normal healthy individuals [51]. The latest metabolomics study has shown that levels in the serum of a variety of metabolites, including glucuronic acid, were reduced in patients with hepatitis B cirrhosis in comparison to healthy individuals [52].
Metabolome responses of the sea cucumber Apostichopus japonicus to multiple environmental stresses: Heat and hypoxia
2019, Marine Pollution BulletinCitation Excerpt :This sugar belongs to a class of compounds known as rare sugars, which are monosaccharides and monosaccharide derivatives that rarely exist in nature (Granstrom et al., 2005). In addition, l-xylulose can be used for medical and clinical diagnosis of conditions, including acute or chronic hepatitis and liver cirrhosis (Oka et al., 1976). Furthermore, metabolites involved in the biosynthesis of other secondary metabolites were significantly decreased under heat plus hypoxia; hypoxic stress produced similar results, but heat stress produced the opposite effect.
Coupling xylitol dehydrogenase with NADH oxidase improves L-xylulose production in Escherichia coli culture
2017, Enzyme and Microbial TechnologyCitation Excerpt :Interest in rare sugars is attributed to their potential applications in pharmaceutical and food industries including antiviral drugs [2–4], anti-cancer or tumor treatments [5], drug building blocks [6], and as low-calorie sweeteners [7]. l-xylulose is a rare ketopentose which inhibits yeast α-glucosidase [8] and is an indicator of hepatitis or liver cirrhosis [9]. This pentose is also a precursor of other rare sugars such as l-xylose or l-lyxose [10,11].
Efficient enzymatic synthesis of l-rhamnulose and l-fuculose
2016, Bioorganic and Medicinal Chemistry Letters