Inhibition of experimental autoimmune uveitis by retinal photoreceptor antigens coupled to spleen cells☆
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Immunomodulatory and immunoregulatory nanomedicines for autoimmunity
2021, Seminars in ImmunologyCitation Excerpt :Enriched delivery of autoantigenic molecules to specific cell types of the immune system via NPs/MPs, specifically those with phagocytic or scavenging properties, has the potential to address this limitation and elicit not only autoantigen-specific deletional tolerance but possibly also the activation of autoantigen-specific regulatory T-cells (Treg cells) (Table 2). The outcome of early studies using peptide-loaded ethylene carbodiimide (ECDI)-fixed splenocytes [27,28] suggested that it might be possible to induce autoantigen-specific tolerance via systemic delivery of peptide-coated/loaded MPs. Indeed, intravenous delivery of peptide-coated/loaded PLG- and carboxylated polystyrene-based MPs prevented the onset of relapsing-remitting EAE (RR-EAE) in SJL/J mice, albeit only when the MPs delivered the same peptide that was used to induce disease (Proteolipid protein (PLP)178-191).
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2008, Journal of the Neurological SciencesThe immunopathogenesis and regulation of T-cell-mediated demyelinating diseases
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Supported in part by the Retina Service, Wills Eye Hospital, National Institutes of Health Grants EY5095 and BRSG5510, the Pennsylvania Lions Sight Conservation and Eye Research Foundation, Research to Prevent Blindness, Inc., the Crippled Childrens Vitreo-Retinal Research Foundation (David Meyer, M.D., Director), the Elizabeth C. King Trust, and the Grampian Health Board, Aberdeen, Scotland (H. S. Dua). H. S. Dua, M.D., Ph.D., is the Henry and Corinne Bower Retina Research Scholar. Larry A. Donoso, M.D., Ph.D., is the Thomas D. Duane Professor of Ophthalmology. Dale S. Gregerson is an RPB Senior Scientific Investigator.