Respiratory rhythm generator neurons in medulla of brainstem-spinal cold preparation from newborn rat
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2024, Respiratory Physiology and NeurobiologyDual orexin receptor blocker suvorexant attenuates hypercapnic ventilatory augmentation in mice
2022, Brain ResearchCitation Excerpt :To this end, expressions of paired like homeobox 2b (Phox2b) and neurokinin 1 receptor (NK1R)/somatostatin (SST) were investigated in the parafacial respiratory group/retrotrapezoid nucleus (pFRG/RTN) and in the preBötzinger complex (preBötC), respectively. The pFRG/RTN is a primary site of hypercapnia sensing (Onimaru et al., 2009) and also a distinct respiratory rhythm generator in the medulla, whose preinspiratory and postinspiratory active (“Onimaru-type Pre-I”) neurons contribute to the control of breathing (Onimaru and Homma, 1987; Onimaru et al., 1995; Onimaru and Homma, 2003; Onimaru et al., 2006). The preBötC is also a distinct region which generates respiratory rhythm in the medulla (Smith et al., 1991; Kuwana et al., 2006; Koshiya et al., 2014).
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2022, Handbook of Clinical NeurologyExcitatory and inhibitory modulation of parafacial respiratory neurons in the control of active expiration
2021, Respiratory Physiology and NeurobiologyInhibitory Thoracic Interneurons are not Essential to Generate the Rostro-caudal Gradient of the Thoracic Inspiratory Motor Activity in Neonatal Rat
2019, NeuroscienceCitation Excerpt :The range of frequency was 3–30 Hz. Since the inspiratory burst is organized in the medulla (Onimaru and Homma, 1987; Smith et al., 1991), this phenomenon could come from a time-dependent change of the preparations rather than the effects of strychnine on the thoracic spinal cord. The optical signals during the seizure-like activity were quite different from the inspiratory optical signals.
The Expression of Galanin in the Parafacial Respiratory Group and its Effects on Respiration in Neonatal Rats
2018, NeuroscienceCitation Excerpt :All neurons exhibited depolarization and firing (398 ± 173 ms) prior to the onset of C4 bursts in single bursters and the first C4 burst in a bursting episode in episodic bursters (see subsequent section). Approximately half the neurons displayed the classic “biphasic” pattern, with firing ceasing during C4 bursts and resuming following inspiratory offset (Onimaru and Homma, 1987). The remainder were of the ‘throughout’ type: lacking inhibition during inspiration and thus firing throughout that phase and after its offset (Onimaru and Homma, 1987, 1992; Onimaru et al., 2012; Ballanyi et al., 1999).
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We thank Dr. A. Simpson for help with the manuscript.