Elsevier

Brain Research

Volume 403, Issue 2, 17 February 1987, Pages 380-384
Brain Research

Respiratory rhythm generator neurons in medulla of brainstem-spinal cold preparation from newborn rat

https://doi.org/10.1016/0006-8993(87)90080-1Get rights and content

Abstract

Rhythmic neuronal activity preceding C4 inspiratory activity (Pre-I neuron activity) was recorded in rostral ventrolateral (near ventral surface) medulla of brainstem-spinal cord preparation isolated from newborn rat. Vagal stimulation inhibited C4 activity but not Pre-I neuron activity. Rhythmic Pre-I neuron-like activity was still recorded in the block of rostral medulla after transection. Results suggest that Pre-I neurons generate the basic respiratory rhythm and trigger inspiratory activity.

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We thank Dr. A. Simpson for help with the manuscript.

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