Effects of dietary selenium on mood in healthy men living in a metabolic research unit
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Lower serum selenium concentration associated with anxiety in children
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2022, Environmental ResearchCitation Excerpt :Although the neurobiological mechanisms by which Se promotes neurodevelopment are not fully understood, both the modulatory effects of Se on thyroid function and the protection of developing neural cells from oxidative damage could exert beneficial effects on cognitive and emotional maturation (Esposito et al., 1997; Sher, 2000). Of note, several human studies have demonstrated the involvement of Se deficiency in mood disorders (Benton, 2002; Hawkes and Hornbostel, 1996). Findings from animal models also support the anxiolytic and antidepressant effects of Se (Casaril et al., 2019; Sousa et al., 2018).
Trace elements in drinking water and the incidence of attention-deficit hyperactivity disorder
2021, Journal of Trace Elements in Medicine and BiologyBeneficial effects of selenium against the behavioral consequences of lipopolysaccharide administration in rats
2021, Learning and MotivationAntidepressant and anxiolytic-like activity of sodium selenite after acute treatment in mice
2017, Pharmacological ReportsCitation Excerpt :Some studies on sodium selenite demonstrated its efficacy in different animal AD [21,27,28] and epilepsy models [8,29]. Moreover, Se deficits have been related to depressive behaviors, while Se supplementation has been observed to improve mood and decrease anxiety [2,30–33]. All above-mentioned studies suggest that Se plays a crucial role in the CNS, is a potent protective agent for neurons and may be potentially helpful as preventive or therapeutic agent in neuropsychiatric disorders, however its mechanism of action is not well understood and requires further investigation.
This research was supported by the U.S. Department of Agriculture. The views expressed are those of the authors and do not necessarily reflect the views of the U.S. Department of Agriculture or the Agricultural Research Service. Mention of a product name is not an endorsement by the U.S. Department of Agriculture or the Agricultural Research Service.