Elsevier

Biological Psychiatry

Volume 30, Issue 8, 15 October 1991, Pages 817-829
Biological Psychiatry

Effects of partial sleep deprivation on the diurnal variation of mood and motor activity in major depression

https://doi.org/10.1016/0006-3223(91)90237-GGet rights and content

Abstract

Partial sleep deprivation (PSD), keeping a subject awake from 2 AM to 9 PM produces an acute mood improvement in 60% of patients with major depression. We sought to characterize the timing, subcomponent mood, and motor activity changes of this response. Thirty-seven subjects with major depression were rated with the 6-item Hamilton Depression Scale (HAM-6) at 1 PM and completed the Profile of Mood States (POMS) every 2 hr on the day before and day of PSD. Locomotor activity was monitored continously during the trial with an automated device. Bipolar I patients responded more frequently than other groups. Positive mood responders had greater improvement than nonresponders in POMS subscales of depression, tension, confusion, and anger. The mood improvement increased steadily during the day, peaked in late afternoon, and declined thereafter. Responders showed significantly higher levels of locomotor activity on the baseline pre-PSD day than did nonresponders. All subjects increased motor activity following sleep deprivation, however.

References (33)

  • M. Wiegand et al.

    The influence of daytime naps on the therapeutic effect of sleep deprivation

    Biol Psychiatry

    (1987)
  • L.A. Anrade et al.

    REM sleep deprivation in an experimental model of Parkinson's disease

    Arq Neuropsiquiatr

    (1987)
  • P. Bech et al.

    Quantitative rating of depressive states: Correlation between assessment, Beck's self-rating scale and Hamilton's objective rating scale

    Acta Psychiatr Scand

    (1975)
  • P.H. Bertolucci et al.

    Total sleep deprivation and Parkinson's disease

    Arq Neuropsiquiatr

    (1987)
  • A.L. Borberly et al.

    Sleep, sleep deprivation and depression

    Hum Neurobiol

    (1982)
  • M. Hamilton

    A rating scale for depression

    J Neurol Neurosurg Psychiatry

    (1960)
  • Cited by (69)

    • The circadian component of mood disorders: the sleep-wake cycle, biological rhythms, and chronotherapeutics

      2023, Encyclopedia of Sleep and Circadian Rhythms: Volume 1-6, Second Edition
    • Mood and metabolic consequences of sleep deprivation as a potential endophenotype' in bipolar disorder

      2013, Journal of Affective Disorders
      Citation Excerpt :

      There was a bidirectional relationship between sleep and mood that total wake time was associated with negative mood in the next morning and evening negative mood was significantly associated with subsequent total wake time (Talbot et al., 2012). High vigilance, high behavioral activation, high levels of confusion, and low levels of tiredness are typical responses to sleep deprivation (Bouhuys et al., 1989, 1995; Selvi et al., 2007; Szuba et al., 1991). Transmitter metabolites found in urine and cerebrospinal fluid indicate the linkages of low peripheral sympathetic activity and high central noradrenergic activity to sleep deprivation (Baumgartner et al., 1990, 1990; Kuhs and Tolle, 1991).

    • Insomnia comorbid to severe psychiatric illness

      2013, Sleep Medicine Clinics
      Citation Excerpt :

      A thorough review of early symptoms of mania and depression by Jackson and colleagues,38 identified sleep disturbance as the most common prodrome of manic relapse and the sixth most common prodrome of depressive relapse in BD. In response to experimental sleep deprivation, a substantial proportion of individuals with BD depression show a rapid alleviation of depressed mood, but a subset of participants experienced an onset of hypomania or mania.39–41 Furthermore, a recent cross-sectional study found that patients with BD who habitually slept fewer than 6 hours a night exhibited both greater manic and depressive symptoms relative to patients with BD that slept between 6.5 and 8.5 hours.34

    • Neuroimaging in Sleep and Sleep Disorders

      2009, Sleep Disorders Medicine: Basic Science, Technical Considerations, and Clinical Aspects: Third Edition
    View all citing articles on Scopus
    View full text