Elsevier

Biological Psychiatry

Volume 25, Issue 8, 15 April 1989, Pages 1003-1013
Biological Psychiatry

Visual evoked potentials in dementia: A meta-analysis and empirical study of Alzheimer's disease patients,☆☆

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Abstract

A meta-analytic review of flash and pattern reversal visual evoked potential research indicates that elderly demented patients have longer P100 latencies than age-matched control subjects. In the present empirical research, patients with research diagnoses of probable Alzheimer's disease were compared with sex- and age-matched control subjects using P100 latencies of visual evoked potentials (VEP) elicited by flash and pattern reversal. As compared to control subjects, Alzheimer's disease patients showed significantly longer P100 latencies of the VEP elicited by pattern reversal; the flash P100 only marginally distinguished them. These findings are discussed within the context of VEP recording practices, patient selection, sex and age matching of control subjects, and the visual system.

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    Supported in part by the State of California Department of Mental Health Research Program.

    ☆☆

    Portions of this material were presented at the 43rd Annual Convention of the Society of Biological Psychiatry, Montreal, Canada, May 1988.

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